Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T02728 Target Info
Target Name Neurotensin receptor type 1 (NTSR1)
Synonyms NTSR1; NTRH; NTR1; NTR subtype 1; NT-R1; NT-R-1; High-affinity levocabastine-insensitive neurotensin receptor
Target Type Clinical trial Target
Gene Name NTSR1
Biochemical Class GPCR rhodopsin
UniProt ID
NTR1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: [(2r)-2-Octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-Tris(Oxidanyl)-4,5-Diphosphonooxy-Cyclohexyl]oxy-Phosphoryl]oxy-Propyl] Octanoate Ligand Info
Structure Description neurotensin receptor and arrestin2 complex PDB:6UP7
Method Electron microscopy Resolution 4.20 Å Mutation Yes [1]
PDB Sequence
PSSELDVNTD
59
IYSKVLVTAV
69
YLALFVVGTV
79
GNTVTAFTLA
89
RKKSLQSLQS
99

TVHYHLGSLA
109
LSDLLTLLLA
119
MPVELYNFIW
129
VHHPWAFGDA
139
GCRGYYFLRD
149

ACTYATALNV
159
ASLSVERYLA
169
ICHPFKAKTL
179
MSRSRTKKFI
189
SAIWLASALL
199

AVPMLFTMGE
209
QNRSADGQHA
219
GGLVCTPTIH
229
TATVKVVIQV
239
NTFMSFIFPM
249

VVISVLNTII
259
ANKLTVMVRQ
269
AAEQFSMAIE
291
PGRVQALRHG
301
VRVLRAVVIA
311

FVVCWLPYHV
321
RRLMFCYISD
331
EQWTPFLYDF
341
YHYFYMVTNA
351
LFYVSSTINP
361

ILYNLVSANF
371
RHIFLATLAC
381
LC
Residue
Distance (Å)
ALA85
4.842
PHE86
3.501
ALA89
3.090
Residue
Distance (Å)
TYR103
3.111
LEU110
3.363
ARG182
2.597
References  Top
REF 1 Structure of the neurotensin receptor 1 in complex with beta-arrestin 1. Nature. 2020 Mar;579(7798):303-308.

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