Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T04303 Target Info
Target Name TGF-beta-stimulated factor 1 (STK16)
Synonyms hPSK; Tyrosine-protein kinase STK16; TSF1; TSF-1; Serine/threonine-protein kinase 16; Protein kinase PKL12; PKL12; Myristoylated and palmitoylated serine/threonine-protein kinase; MPSK1; MPSK
Target Type Literature-reported Target
Gene Name STK16
UniProt ID
STK16_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Staurosporine Ligand Info
Structure Description Crystal structure of the human Serine-threonine Kinase 16 in complex with staurosporine PDB:2BUJ
Method X-ray diffraction Resolution 2.60 Å Mutation Yes [1]
PDB Sequence
NLYFQGHMVI
14
IDNKHYLFIQ
24
KLGEFSYVDL
36
VEGLHDGHFY
46
ALKRILCHEQ
56

QDREEAQREA
66
DMHRLFNHPN
76
ILRLVAYCLR
86
ERGAKHEAWL
96
LLPFFKRGTL
106

WNEIERLKDK
116
GNFLTEDQIL
126
WLLLGICRGL
136
EAIHAKGYAH
146
RDLKPTNILL
156

GDEGQPVLMD
166
LGSMNQACIH
176
VEGSRQALTL
186
QDWAAQRCTI
196
SYRAPELFSV
206

QSHCVIDERT
216
DVWSLGCVLY
226
AMMFGEGPYD
236
MVFQKGDSVA
246
LAVQNQIPQS
258

PRHSSALWQL
268
LNSMMTVDPH
278
QRPHIPLLLS
288
QLEALQPPAP
298
G
Residue
Distance (Å)
LEU26
3.449
GLY27
3.856
GLU28
3.350
VAL34
3.622
ALA47
3.626
LYS49
3.966
CYS53
3.837
HIS54
3.867
GLU55
4.301
ARG59
3.869
LEU78
4.421
GLU87
3.120
Residue
Distance (Å)
GLY89
4.504
ALA90
3.744
HIS92
3.154
LEU98
3.979
PRO99
3.039
PHE100
3.415
PHE101
2.869
LYS102
4.754
GLY104
4.079
THR152
3.737
LEU155
3.938
MET165
3.257
References  Top
REF 1 Crystal Structure of the Human Serine-Threonine Kinase 16 in Complex with Staurosporine

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