Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T04696 | Target Info | |||
| Target Name | Tyrosyl-DNA phosphodiesterase 2 (TDP2) | ||||
| Synonyms | hTDP2; VPg unlinkase; Tyrosyl-RNA phosphodiesterase; Tyr-DNA phosphodiesterase 2; TRAF and TNF receptor-associated protein; TDP2; ETS1-associated protein II; ETS1-associated protein 2; EAPII; 5'-tyrosyl-DNA phosphodiesterase; 5'-Tyr-DNA phosphodiesterase | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | TDP2 | ||||
| Biochemical Class | Phosphoric diester hydrolase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 2,4-Dioxo-10-[3-(1h-Tetrazol-5-Yl)phenyl]-2,3,4,10-Tetrahydropyrimido[4,5-B]quinoline-8-Carbonitrile | Ligand Info | |||||
| Structure Description | Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2 in complex with a small molecule inhibitor | PDB:5J3S | ||||
| Method | X-ray diffraction | Resolution | 3.40 Å | Mutation | Yes | [1] |
| PDB Sequence |
HMFSLITWNI
121 DGLDLNNLSE131 RARGVCSYLA141 LYSPDVIFLQ151 EVIPPYYSYL161 KKRSSNYEII 171 TGHEEGYFTA181 IMLKKSRVKL191 KSQEIIPFPS201 TKMMRNLLCV211 HVNVSGNELC 221 LMTSHLESTR231 GHAAERMNQL241 KMVLKKMQEA251 VIFAGDTNLR266 DREVTRSGGL 276 PNNIVDVWEF286 LGKPKHCQYT296 WDTQMNSNLG306 ITAACKLRFD316 RIFFRIIPRS 331 LDLLGLEKLD341 CGRFPSDHWG351 LLCNLD
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochem J. 2016 Jul 1;473(13):1869-79. | ||||
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