Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T04773 Target Info
Target Name Stromal cell-derived factor 1 (CXCL12)
Synonyms hSDF-1; SDF1B; SDF1A; SDF1; SDF-1; Pre-B cell growth-stimulating factor; Pre-B cell growth stimulating factor; PBSF; Intercrine reduced in hepatomas; IRH; HIRH; C-X-C motif chemokine 12
Target Type Clinical trial Target
Gene Name CXCL12
Biochemical Class Cytokine: CXC chemokine
UniProt ID
SDF1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 1-Phenyl-3-[4-(1h-Tetrazol-5-Yl)phenyl]urea Ligand Info
Structure Description Crystal structure of CXCL12 in complex with inhibitor PDB:4UAI
Method X-ray diffraction Resolution 1.90 Å Mutation No [1]
PDB Sequence
KPVSLSYRCP
10
CRFFESHVAR
20
ANVKHLKILN
30
TPNCALQIVA
40
RLKNNNRQVC
50

IDPKLKWIQE
60
YLEKALNK
Residue
Distance (Å)
GLU15
2.704
HIS17
3.825
VAL18
3.862
ALA19
3.258
ASN22
3.092
Residue
Distance (Å)
LEU42
3.487
ASN44
4.027
ASN45
3.358
ARG47
3.119
VAL49
3.655
References  Top
REF 1 Structural analysis of a novel small molecule ligand bound to the CXCL12 chemokine. J Med Chem. 2014 Nov 26;57(22):9693-9.

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