Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T07507 | Target Info | |||
| Target Name | Myosin-7 (MYH7) | ||||
| Synonyms | Myosin heavy chain, cardiac muscle beta isoform; Myosin heavy chain slow isoform; Myosin heavy chain 7; MyHCslow; MyHCbeta; MYH7 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | MYH7 | ||||
| Biochemical Class | TRAFAC class myosin-kinesin ATPase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: AMP-PNP | Ligand Info | |||||
| Structure Description | Cardiac human myosin S1dC, beta isoform complexed with Mn-AMPPNP | PDB:4DB1 | ||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [1] |
| PDB Sequence |
GGDSEMAVFG
10 AAAPYLRKSE20 KERLEAQTRP30 FDLKKDVFVP40 DDKQEFVKAK50 IVSREGGKVT 60 AETEYGKTVT70 VKEDQVMQQN80 PPKFDKIEDM90 AMLTFLHEPA100 VLYNLKDRYG 110 SWMIYTYSGL120 FCVTVNPYKW130 LPVYTPEVVA140 AYRGKKRSEA150 PPHIFSISDN 160 AYQYMLTDRE170 NQSILITGES180 GAGKTVNTKR190 VIQYFAVIAA200 IGDRGKGTLE 217 DQIIQANPAL227 EAFGNAKTVR237 NDNSSRFGKF247 IRIHFGATGK257 LASADIETYL 267 LEKSRVIFQL277 KAERDYHIFY287 QILSNKKPEL297 LDMLLITNNP307 YDYAFISQGE 317 TTVASIDDAE327 ELMATDNAFD337 VLGFTSEEKN347 SMYKLTGAIM357 HFGNMKFKLK 367 QREEQAEPDG377 TEEADKSAYL387 MGLNSADLLK397 GLCHPRYVTK413 GQNVQQVIYA 423 TGALAKAVYE433 RMFNWMVTRI443 NATLETKQPR453 QYFIGVLDIA463 GFEIFDFNSF 473 EQLCINFTNE483 KLQQFFNHHM493 FVLEQEEYKK503 EGIEWTFIDF513 GMDLQACIDL 523 IEKPMGIMSI533 LEEECMFPKA543 TDMTFKAKLF553 DNHLGKSANF563 QKPRNPEAHF 577 SLIHYAGIVD587 YNIIGWLQKN597 KDPLNETVVG607 LYQKSSLKLL617 STLFANYAFQ 645 TVSALHRENL655 NKLMTNLRST665 HPHFVRCIIP675 NETKSPGVMD685 NPLVMHQLRC 695 NGVLEGIRIC705 RKGFPNRILY715 AEKLLSSLDI751 DHNQYKFGHT761 KVFFKAGLLG 771 LLEEMR
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TYR115
4.782
ASN126
2.923
PRO127
3.357
TYR128
3.798
LYS129
3.358
TRP130
4.117
TYR134
3.405
GLU179
3.762
SER180
2.913
GLY181
2.795
ALA182
3.404
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cardiac human myosin S1dC, beta isoform complexed with Mn-AMPPNP | ||||
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