Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T11192 Target Info
Target Name ADAM metallopeptidase 33 (ADAM33)
Synonyms UNQ873/PRO1891; Disintegrin and metalloproteinase domain-containing protein 33; C20orf153; ADAM 33
Target Type Patented-recorded Target
Gene Name ADAM33
Biochemical Class Peptidase
UniProt ID
ADA33_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Marimastat Ligand Info
Structure Description Crystal structure of the catalytic domain of human ADAM 33 PDB:1R55
Method X-ray diffraction Resolution 1.58 Å Mutation Yes [1]
PDB Sequence
TRKYLELYIV
217
ADHTLFLTRH
227
RNLQHTKQRL
237
LEVANYVDQL
247
LRTLDIQVAL
257

TGLEVWTERD
267
RSRVTQDANA
277
TLWAFLQWRR
287
GLWAQRPHDS
297
AQLLTGRAFQ
307

GATVGLAPVE
317
GMCRAESSGG
327
VSTDHSELPI
337
GAAATMAHEI
347
GHSLGLSHDP
357

DGCCVEAAAE
367
SGGCVMAAAT
377
GHPFPRVFSA
387
CSRRQLRAFF
397
RKGGGACLSN
407

APS
Residue
Distance (Å)
GLY308
4.447
ALA309
3.039
THR310
3.418
VAL311
2.804
GLY312
2.833
LEU313
4.131
ALA314
4.970
ALA341
4.843
THR342
3.540
Residue
Distance (Å)
HIS345
3.155
GLU346
2.784
HIS349
2.994
HIS355
2.841
ALA374
3.520
ALA375
3.354
ALA376
3.386
THR377
2.925
References  Top
REF 1 Crystal structure of the catalytic domain of human ADAM33. J Mol Biol. 2004 Jan 2;335(1):129-37.

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