Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T11615 | Target Info | |||
Target Name | Cystine/glutamate transporter (SLC7A11) | ||||
Synonyms | XCT; X(c)-cystine transporter; X(c)- plasma membrane cystine transporter; Solute carrier family 7 member 11; Calcium channel blocker resistance protein CCBR1; Amino acid transport system xc-; Amino acid transport system XCT | ||||
Target Type | Clinical trial Target | ||||
Gene Name | SLC7A11 | ||||
Biochemical Class | Amino acid-polyamine-organocation | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: 2-[(1S)-1-[4-[2-(4-chloranylphenoxy)ethanoyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one | Ligand Info | |||||
Structure Description | Overall structure of Erastin-bound xCT-4F2hc complex | PDB:7EPZ | ||||
Method | Electron microscopy | Resolution | 3.40 Å | Mutation | No | [1] |
PDB Sequence |
TLLRGVSIII
54 GTIIGAGIFI64 SPKGVLQNTG74 SVGMSLTIWT84 VCGVLSLFGA94 LSYAELGTTI 104 KKSGGHYTYI114 LEVFGPLPAF124 VRVWVELLII134 RPAATAVISL144 AFGRYILEPF 154 FIQCEIPELA164 IKLITAVGIT174 VVMVLNSMSV184 SWSARIQIFL194 TFCKLTAILI 204 IIVPGVMQLI214 KGQTQNFKDA224 FSGRDSSITR234 LPLAFYYGMY244 AYAGWFYLNF 254 VTEEVENPEK264 TIPLAICISM274 AIVTIGYVLT284 NVAYFTTINA294 EELLLSNAVA 304 VTFSERLLGN314 FSLAVPIFVA324 LSCFGSMNGG334 VFAVSRLFYV344 ASREGHLPEI 354 LSMIHVRKHT364 PLPAVIVLHP374 LTMIMLFSGD384 LDSLLNFLSF394 ARWLFIGLAV 404 AGLIYLRYKC414 PDMHRPFKVP424 LFIPALFSFT434 CLFMVALSLY444 SDPFSTGIGF 454 VITLTGVPAY464 YLFIIWDKKP474 RWFRIMSEKI484 TRTLQIILEV494 VPE |
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Ligand Name: Distearoyl phosphatidic acid | Ligand Info | |||||
Structure Description | Overall structure of Erastin-bound xCT-4F2hc complex | PDB:7EPZ | ||||
Method | Electron microscopy | Resolution | 3.40 Å | Mutation | No | [1] |
PDB Sequence |
TLLRGVSIII
54 GTIIGAGIFI64 SPKGVLQNTG74 SVGMSLTIWT84 VCGVLSLFGA94 LSYAELGTTI 104 KKSGGHYTYI114 LEVFGPLPAF124 VRVWVELLII134 RPAATAVISL144 AFGRYILEPF 154 FIQCEIPELA164 IKLITAVGIT174 VVMVLNSMSV184 SWSARIQIFL194 TFCKLTAILI 204 IIVPGVMQLI214 KGQTQNFKDA224 FSGRDSSITR234 LPLAFYYGMY244 AYAGWFYLNF 254 VTEEVENPEK264 TIPLAICISM274 AIVTIGYVLT284 NVAYFTTINA294 EELLLSNAVA 304 VTFSERLLGN314 FSLAVPIFVA324 LSCFGSMNGG334 VFAVSRLFYV344 ASREGHLPEI 354 LSMIHVRKHT364 PLPAVIVLHP374 LTMIMLFSGD384 LDSLLNFLSF394 ARWLFIGLAV 404 AGLIYLRYKC414 PDMHRPFKVP424 LFIPALFSFT434 CLFMVALSLY444 SDPFSTGIGF 454 VITLTGVPAY464 YLFIIWDKKP474 RWFRIMSEKI484 TRTLQIILEV494 VPE |
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TRP128
4.122
LEU132
3.784
VAL178
4.156
SER181
4.306
MET182
3.979
GLY349
4.396
HIS350
4.160
LEU351
3.181
PRO352
3.295
GLU353
3.811
HIS359
4.449
ARG361
3.675
LEU366
3.792
VAL369
4.659
ILE370
3.779
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References | Top | ||||
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REF 1 | The structure of erastin-bound xCT-4F2hc complex?reveals molecular mechanisms underlying erastin-induced ferroptosis. Cell Res. 2022 Jul;32(7):687-690. |
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