Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T13259 | Target Info | |||
| Target Name | Succinate-semialdehyde dehydrogenase (ALDH5A1) | ||||
| Synonyms | Succinic dehydrogenase; Succinate-semialdehyde dehydrogenase, mitochondrial; SSADH; NAD(+)-dependent succinic semialdehyde dehydrogenase; Aldehyde dehydrogenase family 5 member A1 | ||||
| Target Type | Successful Target | ||||
| Gene Name | ALDH5A1 | ||||
| Biochemical Class | Aldehyde/oxo donor oxidoreductase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: adenosine diphosphate | Ligand Info | |||||
| Structure Description | The crystal structure of human SSADH in complex with NAD+ | PDB:2W8R | ||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | Yes | [1] |
| PDB Sequence |
LAGLSAALLR
60 TDSFVGGRWL70 PAAATFPVQD80 PASGAALGMV90 ADCGVREARA100 AVRAAYEAFC 110 RWREVSAKER120 SSLLRKWYNL130 MIQNKDDLAR140 IITAESGKPL150 KEAHGEILYS 160 AFFLEWFSEE170 ARRVYGDIIH180 TPAKDRRALV190 LKQPIGVAAV200 ITPWNFPSAM 210 ITRKVGAALA220 AGCTVVVKPA230 EDTPFSALAL240 AELASQAGIP250 SGVYNVIPCS 260 RKNAKEVGEA270 ICTDPLVSKI280 SFTGSTTTGK290 ILLHHAANSV300 KRVSMELGGL 310 APFIVFDSAN320 VDQAVAGAMA330 SKFRNTGQTA340 VCSNQFLVQR350 GIHDAFVKAF 360 AEAMKKNLRV370 GNGFEEGTTQ380 GPLINEKAVE390 KVEKQVNDAV400 SKGATVVTGG 410 KRHQLGKNFF420 EPTLLCNVTQ430 DMLCTHEETF440 GPLAPVIKFD450 TEEEAIAIAN 460 AADVGLAGYF470 YSQDPAQIWR480 VAEQLEVGMV490 GVNEGLISSV500 ECPFGGVKQS 510 GLGREGSKYG520 IDEYLELKYV530 CYGGL
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ILE201
3.745
THR202
2.861
PRO203
3.957
TRP204
3.643
ASN205
4.407
LYS228
2.614
PRO229
3.836
ALA230
3.465
GLU231
3.169
ALA264
3.514
LYS265
3.899
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Redox-switch modulation of human SSADH by dynamic catalytic loop. EMBO J. 2009 Apr 8;28(7):959-68. | ||||
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