Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T13795 | Target Info | |||
| Target Name | Neuronal acetylcholine receptor alpha-9 (CHRNA9) | ||||
| Synonyms | Nicotinic acetylcholine receptor subunit alpha 9; NACHR alpha 9; CHRNA9 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | CHRNA9 | ||||
| Biochemical Class | Neurotransmitter receptor | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: [3H]methyllycaconitine | Ligand Info | |||||
| Structure Description | Crystal Structure of the Extracellular Domain of the Human Alpha9 Nicotinic Acetylcholine Receptor In Complex with Methyllycaconitine | PDB:4UXU | ||||
| Method | X-ray diffraction | Resolution | 1.71 Å | Mutation | No | [1] |
| PDB Sequence |
GKYAQKLFND
12 LFEDYSNALR22 PVEDTDKVLN32 VTLQITLSQI42 KDMDERNQIL52 TAYLWIRQIW 62 HDAYLTWDRD72 QYDGLDSIRI82 PSDLVWRPDI92 VLYNKADDES102 SEPVNTNVVL 112 RYDGLITWDA122 PAITKSSCVV132 DVTYFPFDNQ142 QCNLTFGSWT152 YNGNQVDIFN 162 ALDSGDLSDF172 IEDVEWEVHG182 MPAVKNVISY192 GCCSEPYPDV202 TFTLLLKRRS 212
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structures of free and antagonist-bound states of human Alpha9 nicotinic receptor extracellular domain. Nat Struct Mol Biol. 2014 Nov;21(11):976-80. | ||||
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