Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T14110 | Target Info | |||
| Target Name | Beta-klotho (KLB) | ||||
| Synonyms | Klotho beta-like protein; BetaKlotho; BKL | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | KLB | ||||
| Biochemical Class | Glycosylase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Beta-D-Glucose | Ligand Info | |||||
| Structure Description | Crystal Structure of Beta-Klotho | PDB:5VAN | ||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | Yes | [1] |
| PDB Sequence |
FSGDGRAIWS
62 QLFLYDTFPK83 NFFWGIGTGA93 LQVEGSWKKD103 GKGPSIWDHF113 IHTHLGSSDS 130 YIFLEKDLSA140 LDFIGVSFYQ150 FSISWPRLFP160 DGIVTVANAK170 GLQYYSTLLD 180 ALVLRNIEPI190 VTLYHWDLPL200 ALQEKYGGWK210 NDTIIDIFND220 YATYCFQMFG 230 DRVKYWITIH240 NPYLVAWHGY250 GTGMHAPGEK260 GNLAAVYTVG270 HNLIKAHSKV 280 WHNYNTHFRP290 HQKGWLSITL300 GSHWIEPQRS310 ENTMDIFKCQ320 QSMVSVLGWF 330 ANPIHGDGDY340 PEGMRKKLFS350 VLPIFSEAEK360 HEMRGTADFF370 AFSFGPNNFK 380 PLNTMAKMGQ390 NVSLNLREAL400 NWIKLEYNNP410 RILIAENGWF420 TDSRVKTEDT 430 TAIYMMKNFL440 SQVLQAIRLD450 EIRVFGYTAW460 SLLDGFEWQD470 AYTIRRGLFY 480 VDFNSKQKER490 KPKSSAHYYK500 QIIRENGFSL510 KESTPDVQGQ520 FPCDFSWGVT 530 ESVLKPEQCT577 DFVNIKKQLE587 MLARMKVTHY597 RFALDWASVL607 PTGQLSAVNR 617 QALRYYRCVV627 SEGLKLGISA637 MVTLYYPTHA647 HLGLPEPLLH657 ADGWLNPSTA 667 EAFQAYAGLC677 FQELGDLVKL687 WITINEPNRL697 SDIYNRSGND707 TYGAAHNLLV 717 AHALAWRLYD727 RQFRPSQRGA737 VSLSLHADWA747 EPANPYADSH757 WRAAERFLQF 767 EIAWFAEPLF777 KTGDYPAAMR787 EYIASKHRRG797 LSSSALPRLT807 EAERRLLKGT 817 VDFCALNHFT827 TRFVMHEQLA837 GSRYDSDRDI847 QFLQDITRLS857 SPTRLAVIPW 867 GVRKLLRWVR877 RNYGDMDIYI887 TASGIDDQAL897 EDDRLRKYYL907 GKYLQEVLKA 917 YLIDKVRIKG927 YYAFKLAEEK937 SKPRFGFFTS947 DFKAKSSIQF957 YNKVISSRGF 967 P
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling. Nature. 2018 Jan 25;553(7689):501-505. | ||||
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