Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T15510 Target Info
Target Name Insulin receptor substrate-1 (IRS1)
Synonyms Insulin receptor substrate 1; IRS-1
Target Type Clinical trial Target
Gene Name IRS1
UniProt ID
IRS1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: L-betagamma-meATP Ligand Info
Structure Description Structure of the Insulin-like Growth Factor 1 Receptor Kinase PDB:1K3A
Method X-ray diffraction Resolution 2.10 Å Mutation Yes [1]
PDB Sequence
GEYVNIEF
Residue
Distance (Å)
TYR8
4.969
Residue
Distance (Å)
References  Top
REF 1 Structure and autoregulation of the insulin-like growth factor 1 receptor kinase. Nat Struct Biol. 2001 Dec;8(12):1058-63.

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