Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T16016 | Target Info | |||
| Target Name | C-C chemokine receptor type 1 (CCR1) | ||||
| Synonyms | SCYAR1; RANTES-R; Macrophage inflammatory protein-1 alpha receptor; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; LD78 receptor; HM145; Chemokine receptor CCR1; CMKR1; CMKBR1; CD191; CCR-1; CC-CKR-1; C-C CKR-1 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | CCR1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | Cryo-EM structure of the CCL15(26-92) bound CCR1-Gi complex | PDB:7VL9 | ||||
| Method | Electron microscopy | Resolution | 2.60 Å | Mutation | Yes | [1] |
| PDB Sequence |
DYGDATPCQK
26 VNERAFGAQL36 LPPLYSLVFV46 IGLVGNILVV56 LVLVQYKRLK66 NMTSIYLLNL 76 AISDLLFLFT86 LPFWIDYKLK96 DDWVFGDAMC106 KILSGFYYTG116 LYSEIFFIIL 126 LTIDRYLAIV136 HAVFALRART146 VTFGVITSII156 IWALAILASM166 PGLYFSKTQW 176 EFTHHTCSLH186 FPHESLREWK196 LFQALKLNLF206 GLVLPLLVMI216 ICYTGIIKIL 226 LRRPNEKKSK236 AVRLIFVIMI246 IFFLFWTPYN256 LTILISVFQD266 FLFTHECEQS 276 RHLDLAVQVT286 EVIAYTHCCV296 NPVIYAFVGE306 RFRKYLRQLF316 HR |
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1. Nat Chem Biol. 2022 Mar;18(3):264-271. | ||||
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