Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T17036 | Target Info | |||
| Target Name | Lysine-specific demethylase 4E (KDM4E) | ||||
| Synonyms | Lysine-specific demethylase 4D-like; KDM4DL; KDM4D-like protein | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | KDM4E | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Pyridine-2,4-dicarboxylic acid | Ligand Info | |||||
| Structure Description | Crystal structure of the human 2-oxoglutarate oxygenase LOC390245 | PDB:2W2I | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [1] |
| PDB Sequence |
HTIMTFYPTM
22 EEFADFNTYV32 AYMESQGAHQ42 AGLAKVIPPK52 EWKARQMYDD62 IEDILIATPL 72 QQVTSGQGGV82 FTQYHKKKKA92 MRVGQYRRLA102 NSKKYQTPPH112 QNFADLEQRY 122 WKSHPGNPPI132 YGADISGSLF142 EESTKQWNLG152 HLGTILDLLE162 QECGVVIEGV 172 NTPYLYFGMW182 KTTFAWHTED192 MDLYSINYLH202 FGEPKTWYVV212 PPEHGQHLER 222 LARELFPDIS232 AFLRHKVALI246 SPTVLKENGI256 PFNCMTQEAG266 EFMVTFPYGY 276 HAGFNHGFNC286 AEAINFATPR296 WIDYGKMAVT315 FSMDPFVRIV325 QPESY |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family. J Biol Chem. 2011 Dec 2;286(48):41616-41625. | ||||
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