Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T17248 | Target Info | |||
| Target Name | Measles virus Fusion glycoprotein (MeV F) | ||||
| Synonyms | Measles virus fusion protein; MV fusion protein; Fusion protein | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | MeV F | ||||
| Biochemical Class | Paramyxoviruses fusion glycoprotein | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 4-Nitro-2-[(phenylacetyl)amino]benzamide | Ligand Info | |||||
| Structure Description | Crystal structure of the prefusion form of measles virus fusion protein in complex with a fusion inhibitor compound (AS-48) | PDB:5YZC | ||||
| Method | X-ray diffraction | Resolution | 2.33 Å | Mutation | No | [1] |
| PDB Sequence |
GVVLAGAALG
124 VATAAQITAG134 IALHQSMLNS144 QAIDNLRASL154 ETTNQAIEAI164 RQAGQEMILA 174 VQGVQDYINN184 ELIPSMNQLS194 CDLIGQKLGL204 KLLRYYTEIL214 SLFGPSLRDP 224 ISAEISIQAL234 SYALGGDINK244 VLEKLGYSGG254 DLLGILESRG264 IKARITHVDT 274 ESYFIVLSIA284 YPTLSEIKGV294 IVHRLEGVSY304 NIGSQEWYTT314 VPKYVATQGY 324 LISNFDESSC334 TFMPEGTVCS344 QNALYPMSPL354 LQECLRGSTK364 SCARTLVSGS 374 FGNRFILSQG384 NLIANCASIL394 CKCYTTGTII404 NQDPDKILTY414 IAADHCPVVE 424 VNGVTIQVGS434 RRYPDAVYLH444 RIDLGPPISL454 ERLDVGTNLG464 NAIAKLEDAK 474 ELLESSD
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structures of the prefusion form of measles virus fusion protein in complex with inhibitors. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2496-2501. | ||||
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