Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T17642 Target Info
Target Name Serine protease HTRA1 (HTRA1)
Synonyms Serine protease 11; L56; High-temperature requirement A serine peptidase 1; HTRA1
Target Type Literature-reported Target
Gene Name HTRA1
Biochemical Class Peptidase
UniProt ID
HTRA1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: B-Octylglucoside Ligand Info
Structure Description HtrA1 catalytic domain, mutationally inactivated PDB:3TJO
Method X-ray diffraction Resolution 2.30 Å Mutation Yes [1]
PDB Sequence
MDPNSLRHKY
169
NFIADVVEKI
179
APAVVHIELF
189
RKLPFSKREV
199
PVASGSGFIV
209

SEDGLIVTNA
219
HVVTNKHRVK
229
VELKNGATYE
239
AKIKDVDEKA
249
DIALIKIDHQ
259

GKLPVLLLGR
269
SSELRPGEFV
279
VAIGSPFSLQ
289
NTVTTGIVST
299
TQDYIQTDAI
322

INYGNAGGPL
332
VNLDGEVIGI
342
NTLKVTAGIS
352
FAIPSDKIKK
362
FLTESHDR
Residue
Distance (Å)
VAL209
3.358
SER210
3.356
LEU214
3.546
LEU364
3.700
Residue
Distance (Å)
THR365
3.843
HIS368
3.469
ASP369
3.608
References  Top
REF 1 Structural and functional analysis of HtrA1 and its subdomains. Structure. 2012 Jun 6;20(6):1040-50.

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