Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T23714 | Target Info | |||
Target Name | B2 bradykinin receptor (BDKRB2) | ||||
Synonyms | Bradykinin B2 receptor; BKR2; BK-2 receptor; BK B(2) receptor; B2R | ||||
Target Type | Successful Target | ||||
Gene Name | BDKRB2 | ||||
Biochemical Class | GPCR rhodopsin | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: Cholesterol | Ligand Info | |||||
Structure Description | Cryo-EM structure of human bradykinin receptor BK2R in complex Gq proteins and kallidin | PDB:7F6I | ||||
Method | Electron microscopy | Resolution | 2.80 Å | Mutation | No | [1] |
PDB Sequence |
CPQVEWLGWL
56 NTIQPPFLWV66 LFVLATLENI76 FVLSVFCLHK86 SSCTVAEIYL96 GNLAAADLIL 106 ACGLPFWAIT116 ISNNFDWLFG126 ETLCRVVNAI136 ISMNLYSSIC146 FLMLVSIDRY 156 LALVKTMSMG166 RMRGVRWAKL176 YSLVIWGCTL186 LLSSPMLVFR196 TMKEYSDEGH 206 NVTACVISYP216 SLIWEVFTNM226 LLNVVGFLLP236 LSVITFCTMQ246 IMQVLRNNEM 256 QKFKEIQTER266 RATVLVLVVL276 LLFIICWLPF286 QISTFLDTLH296 RLGILSSCQD 306 ERIIDVITQI316 ASFMAYSNSC326 LNPLVYVIVG336 KRFRKKSWEV346 YQGVC |
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LEU79
3.803
PHE82
3.421
CYS83
3.679
CYS89
3.144
GLU93
3.849
ILE94
3.871
GLY97
3.451
ASN98
3.314
ALA101
3.675
ILE105
4.301
MET139
4.947
CYS146
4.067
LEU150
3.702
ILE153
4.428
LEU157
3.597
MET165
4.957
|
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Click to View More Binding Site Information of This Target and Ligand Pair |
References | Top | ||||
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REF 1 | Cryo-EM structures of human bradykinin receptor-G(q) proteins complexes. Nat Commun. 2022 Feb 7;13(1):714. |
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