Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T24089 Target Info
Target Name Cholecystokinin (CCK)
Synonyms Procholecystokinin; CCK
Target Type Literature-reported Target
Gene Name CCK
Biochemical Class Gastrin cholecystokinin
UniProt ID
CCKN_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: tyrosine O-sulfate Ligand Info
Structure Description Human Cholecystokinin 1 receptor (CCK1R) Gs complex PDB:7MBX
Method Electron microscopy Resolution 1.95 Å Mutation Yes [1]
PDB Sequence
DMGWMDF
Residue
Distance (Å)
ASP1
1.329
MET3
1.328
GLY4
3.808
Residue
Distance (Å)
TRP5
3.972
MET6
3.353
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References  Top
REF 1 Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. PLoS Biol. 2021 Jun 4;19(6):e3001295.

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