Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T24211 | Target Info | |||
Target Name | C1 esterase inhibitor (SERPING1) | ||||
Synonyms | Serpin G1; SERPING1; Plasma protease C1 inhibitor; C1inhibiting factor; C1Inh; C1 Inh | ||||
Target Type | Successful Target | ||||
Gene Name | SERPING1 | ||||
Biochemical Class | Serpin protein | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: (2S,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol | Ligand Info | |||||
Structure Description | Active human c1-inhibitor in complex with dextran sulfate | PDB:5DUQ | ||||
Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | No | [1] |
PDB Sequence |
STEAVLGDAL
124 VDFSLKLYHA134 FSAMKKVETN144 MAFSPFSIAS154 LLTQVLLGAG164 ENTKTNLESI 174 LSYPKDFTCV184 HQALKGFTTK194 GVTSVSQIFH204 SPDLAIRDTF214 VNASRTLYSS 224 SPRVLSNNSD234 ANLELINTWV244 AKNTNNKISR254 LLDSLPSDTR264 LVLLNAIYLS 274 AKWKTTFDPK284 KTRMEPFHFK294 NSVIKVPMMN304 SKKYPVAHFI314 DQTLKAKVGQ 324 LQLSHNLSLV334 ILVPQNLKHR344 LEDMEQALSP354 SVFKAIMEKL364 EMSKFQPTLL 374 TLPRIKVTTS384 QDMLSIMEKL394 EFFDFSYDLN404 LCGLTEDPDL414 QVSAMQHQTV 424 LELTETGVEA434 AAASAISVAR444 TLLVFEVQQP454 FLFMLWDQQH464 KFPVFMGRVY 474 DP
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References | Top | ||||
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REF 1 | How Dextran Sulfate Affects C1-inhibitor Activity: A Model for Polysaccharide Potentiation. Structure. 2016 Dec 6;24(12):2182-2189. |
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