Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T25861 | Target Info | |||
| Target Name | Short transient receptor potential channel 3 (TRPC3) | ||||
| Synonyms | TrpC3; Htrp3; Htrp-3 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | TRPC3 | ||||
| Biochemical Class | Transient receptor potential catioin channel | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Cholesterol hemisuccinate | Ligand Info | |||||
| Structure Description | Structure of TRPC3 at 2.7 angstrom in high calcium state | PDB:7DXB | ||||
| Method | Electron microscopy | Resolution | 2.70 Å | Mutation | No | [1] |
| PDB Sequence |
GPAFMFNTSL
24 TAEEERFLDA34 AEYGNIPVVR44 KMLEESKTLN54 VNCVDYMGQN64 ALQLAVGNEH 74 LEVTELLLKK84 ENLARIGDAL94 LLAISKGYVR104 IVEAILNHPG114 FAASKRLTLS 124 PCEQELQDDD134 FYAYDEDGTR144 FSPDITPIIL154 AAHCQKYEVV164 HMLLMKGARI 174 ERPHDYFCKC184 GDCMEKQRHD194 SFSHSRSRIN204 AYKGLASPAY214 LSLSSEDPVL 224 TALELSNELA234 KLANIEKEFK244 NDYRKLSMQC254 KDFVVGVLDL264 CRDSEEVEAI 274 LNGDASLSRV297 KLAIKYEVKK307 FVAHPNCQQQ317 LLTIWYENLS327 GLREQTIAIK 337 CLVVLVVALG347 LPFLAIGYWI357 APCSRLGKIL367 RSPFMKFVAH377 AASFIIFLGL 387 LVFNASDRFE397 GITTLPNITV407 TDYPKQIFRV417 KTTQFTWTEM427 LIMVWVLGMM 437 WSECKELWLE447 GPREYILQLW457 NVLDFGMLSI467 FIAAFTARFL477 AFLQATKAQQ 487 YVDSYVQESD497 LSEVTLPPEI507 QYFTYARDKW517 LPSDPQIISE527 GLYAIAVVLS 537 FSRIAYILPA547 NESFGPLQIS557 LGRTVKDIFK567 FMVLFIMVFF577 AFMIGMFILY 587 SYYLGAKVNA597 AFTTVEESFK607 TLFWSIFGLS617 EVTSVVLKYD627 HKFIENIGYV 637 LYGIYNVTMV647 VVLLNMLIAM657 INSSYQEIED667 DSDVEWKFAR677 SKLWLSYFDD 687 GKTLPPPFSL697 VPQPTRYQQI766 MKRLIKRYVL776 KAQVDKENDE786 VNEGELKEIK 796 QDISSLRYEL806 LEDKSQATEE816 LAILIHKL
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TRP322
3.952
TYR323
2.864
ILE334
4.771
LYS337
3.493
CYS338
4.952
VAL341
3.647
PHE371
3.225
PHE374
3.983
ALA378
4.703
ILE382
3.543
MET437
3.713
PHE462
4.438
SER466
4.844
ILE469
4.007
ALA470
3.599
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: [(2S)-2-[(E)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate | Ligand Info | |||||
| Structure Description | Structure of TRPC3 at 2.7 angstrom in high calcium state | PDB:7DXB | ||||
| Method | Electron microscopy | Resolution | 2.70 Å | Mutation | No | [1] |
| PDB Sequence |
GPAFMFNTSL
24 TAEEERFLDA34 AEYGNIPVVR44 KMLEESKTLN54 VNCVDYMGQN64 ALQLAVGNEH 74 LEVTELLLKK84 ENLARIGDAL94 LLAISKGYVR104 IVEAILNHPG114 FAASKRLTLS 124 PCEQELQDDD134 FYAYDEDGTR144 FSPDITPIIL154 AAHCQKYEVV164 HMLLMKGARI 174 ERPHDYFCKC184 GDCMEKQRHD194 SFSHSRSRIN204 AYKGLASPAY214 LSLSSEDPVL 224 TALELSNELA234 KLANIEKEFK244 NDYRKLSMQC254 KDFVVGVLDL264 CRDSEEVEAI 274 LNGDASLSRV297 KLAIKYEVKK307 FVAHPNCQQQ317 LLTIWYENLS327 GLREQTIAIK 337 CLVVLVVALG347 LPFLAIGYWI357 APCSRLGKIL367 RSPFMKFVAH377 AASFIIFLGL 387 LVFNASDRFE397 GITTLPNITV407 TDYPKQIFRV417 KTTQFTWTEM427 LIMVWVLGMM 437 WSECKELWLE447 GPREYILQLW457 NVLDFGMLSI467 FIAAFTARFL477 AFLQATKAQQ 487 YVDSYVQESD497 LSEVTLPPEI507 QYFTYARDKW517 LPSDPQIISE527 GLYAIAVVLS 537 FSRIAYILPA547 NESFGPLQIS557 LGRTVKDIFK567 FMVLFIMVFF577 AFMIGMFILY 587 SYYLGAKVNA597 AFTTVEESFK607 TLFWSIFGLS617 EVTSVVLKYD627 HKFIENIGYV 637 LYGIYNVTMV647 VVLLNMLIAM657 INSSYQEIED667 DSDVEWKFAR677 SKLWLSYFDD 687 GKTLPPPFSL697 VPQPTRYQQI766 MKRLIKRYVL776 KAQVDKENDE786 VNEGELKEIK 796 QDISSLRYEL806 LEDKSQATEE816 LAILIHKL
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: (2s)-3-{[(S)-(2-Aminoethoxy)(Hydroxy)phosphoryl]oxy}-2-(Hexanoyloxy)propyl Hexanoate | Ligand Info | |||||
| Structure Description | Structure of the human TRPC3 in a lipid-occupied, closed state | PDB:6CUD | ||||
| Method | Electron microscopy | Resolution | 3.30 Å | Mutation | No | [2] |
| PDB Sequence |
TSLTAEEERF
31 LDAAEYGNIP41 VVRKMLEESK51 TLNVNCVDYM61 GQNALQLAVG71 NEHLEVTELL 81 LKKENLARIG91 DALLLAISKG101 YVRIVEAILN111 HPGFAASKRL121 TLSPCEQELQ 131 DDDFYAYDED141 GTRFSPDITP151 IILAAHCQKY161 EVVHMLLMKG171 ARIERPHDYF 181 CKCGDCMEKQ191 RHDSFSHSRS201 RINAYKGLAS211 PAYLSLSSED221 PVLTALELSN 231 ELAKLANIEK241 EFKNDYRKLS251 MQCKDFVVGV261 LDLCRDSEEV271 EAILNGDLEA 292 SLSRVKLAIK302 YEVKKFVAHP312 NCQQQLLTIW322 YENLSGLREQ332 TIAIKCLVVL 342 VVALGLPFLA352 IGYWIAPCSR362 LGKILRSPFM372 KFVAHAASFI382 IFLGLLVFNA 392 SDRFEGITTL402 PNITVTDYPK412 QIFRVKTTQF422 TWTEMLIMVW432 VLGMMWSECK 442 ELWLEGPREY452 ILQLWNVLDF462 GMLSIFIAAF472 TARFLAFLQA482 TKAQQYVDSY 492 VQESDLSEVT502 LPPEIQYFTY512 ARDKWLPSDP522 QIISEGLYAI532 AVVLSFSRIA 542 YILPANESFG552 PLQISLGRTV562 KDIFKFMVLF572 IMVFFAFMIG582 MFILYSYYLG 592 AKVNAAFTTV602 EESFKTLFWS612 IFGLSEVTSV622 VLKYDHKFIE632 NIGYVLYGIY 642 NVTMVVVLLN652 MLIAMINSSY662 QEIEDDSDVE672 WKFARSKLWL682 SYFDDNQPTR 762 YQQIMKRLIK772 RYVLKAQVDK782 ENDEVNEGEL792 KEIKQDISSL802 RYEL |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .6OE or .6OE2 or .6OE3 or :36OE;style chemicals stick;color identity;select .A:322 or .A:323 or .A:337 or .A:341 or .A:371 or .A:374 or .A:378 or .A:379 or .A:382 or .A:544 or .A:545 or .A:547 or .A:548 or .A:549 or .A:551 or .A:677; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2,3-Dihexanoyl-sn-glycerol | Ligand Info | |||||
| Structure Description | Structure of the human TRPC3 in a lipid-occupied, closed state | PDB:6CUD | ||||
| Method | Electron microscopy | Resolution | 3.30 Å | Mutation | No | [2] |
| PDB Sequence |
TSLTAEEERF
31 LDAAEYGNIP41 VVRKMLEESK51 TLNVNCVDYM61 GQNALQLAVG71 NEHLEVTELL 81 LKKENLARIG91 DALLLAISKG101 YVRIVEAILN111 HPGFAASKRL121 TLSPCEQELQ 131 DDDFYAYDED141 GTRFSPDITP151 IILAAHCQKY161 EVVHMLLMKG171 ARIERPHDYF 181 CKCGDCMEKQ191 RHDSFSHSRS201 RINAYKGLAS211 PAYLSLSSED221 PVLTALELSN 231 ELAKLANIEK241 EFKNDYRKLS251 MQCKDFVVGV261 LDLCRDSEEV271 EAILNGDLEA 292 SLSRVKLAIK302 YEVKKFVAHP312 NCQQQLLTIW322 YENLSGLREQ332 TIAIKCLVVL 342 VVALGLPFLA352 IGYWIAPCSR362 LGKILRSPFM372 KFVAHAASFI382 IFLGLLVFNA 392 SDRFEGITTL402 PNITVTDYPK412 QIFRVKTTQF422 TWTEMLIMVW432 VLGMMWSECK 442 ELWLEGPREY452 ILQLWNVLDF462 GMLSIFIAAF472 TARFLAFLQA482 TKAQQYVDSY 492 VQESDLSEVT502 LPPEIQYFTY512 ARDKWLPSDP522 QIISEGLYAI532 AVVLSFSRIA 542 YILPANESFG552 PLQISLGRTV562 KDIFKFMVLF572 IMVFFAFMIG582 MFILYSYYLG 592 AKVNAAFTTV602 EESFKTLFWS612 IFGLSEVTSV622 VLKYDHKFIE632 NIGYVLYGIY 642 NVTMVVVLLN652 MLIAMINSSY662 QEIEDDSDVE672 WKFARSKLWL682 SYFDDNQPTR 762 YQQIMKRLIK772 RYVLKAQVDK782 ENDEVNEGEL792 KEIKQDISSL802 RYEL |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FGJ or .FGJ2 or .FGJ3 or :3FGJ;style chemicals stick;color identity;select .A:606 or .A:607 or .A:610 or .A:611; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. Neuron. 2022 Mar 16;110(6):1023-1035.e5. | ||||
| REF 2 | Structure of the human lipid-gated cation channel TRPC3. Elife. 2018 May 4;7:e36852. | ||||
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