Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T27376 | Target Info | |||
| Target Name | GABA(A) receptor delta (GABRD) | ||||
| Synonyms | Gammaaminobutyric acid receptor subunit delta; GABRD; GABA(A) receptor subunit delta | ||||
| Target Type | Successful Target | ||||
| Gene Name | GABRD | ||||
| Biochemical Class | Ligand-gated ion channel | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Gaboxadol | Ligand Info | |||||
| Structure Description | Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with THIP (gaboxadol), histamine and nanobody Nb25 | PDB:7QNC | ||||
| Method | Electron microscopy | Resolution | 2.90 Å | Mutation | No | [1] |
| PDB Sequence |
PNLDGLIAGY
51 ARNFRPGIGG61 PPVNVALALE71 VASIDHISEA81 NMEYTMTVFL91 HQSWRDSRLS 101 YNHTNETLGL111 DSRFVDKLWL121 PDTFIVNAKS131 AWFHDVTVEN141 KLIRLQPDGV 151 ILYSIRITST161 VACDMDLAKY171 PMDEQECMLD181 LESYGYSSED191 IVYYWSESQE 201 HIHGLDKLQL211 AQFTITSYRF221 TTELMNFKSA231 GQFPRLSLHF241 HLRRNRGVYI 251 IQSYMPSVLL261 VAMSWVSFWI271 SQAAVPARVS281 LGITTVLTMT291 TLMVSARSSL 301 PRASAIKALD311 VYFWICYVFV321 FAALVEYAFA331 HFNADADTID428 IYARAVFPAA 438 FAAVNVIYWA448 AYA
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Decane | Ligand Info | |||||
| Structure Description | Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with nanobody Nb25 | PDB:7QN5 | ||||
| Method | Electron microscopy | Resolution | 2.50 Å | Mutation | No | [1] |
| PDB Sequence |
PNLDGLIAGY
51 ARNFRPGIGG61 PPVNVALALE71 VASIDHISEA81 NMEYTMTVFL91 HQSWRDSRLS 101 YNHTNETLGL111 DSRFVDKLWL121 PDTFIVNAKS131 AWFHDVTVEN141 KLIRLQPDGV 151 ILYSIRITST161 VACDMDLAKY171 PMDEQECMLD181 LESYGYSSED191 IVYYWSESQE 201 HIHGLDKLQL211 AQFTITSYRF221 TTELMNFKSA231 GQFPRLSLHF241 HLRRNRGVYI 251 IQSYMPSVLL261 VAMSWVSFWI271 SQAAVPARVS281 LGITTVLTMT291 TLMVSARSSL 301 PRASAIKALD311 VYFWICYVFV321 FAALVEYAFA331 HFNADADTID428 IYARAVFPAA 438 FAAVNVIYWA448 AYA
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Octane | Ligand Info | |||||
| Structure Description | Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with nanobody Nb25 | PDB:7QN5 | ||||
| Method | Electron microscopy | Resolution | 2.50 Å | Mutation | No | [1] |
| PDB Sequence |
PNLDGLIAGY
51 ARNFRPGIGG61 PPVNVALALE71 VASIDHISEA81 NMEYTMTVFL91 HQSWRDSRLS 101 YNHTNETLGL111 DSRFVDKLWL121 PDTFIVNAKS131 AWFHDVTVEN141 KLIRLQPDGV 151 ILYSIRITST161 VACDMDLAKY171 PMDEQECMLD181 LESYGYSSED191 IVYYWSESQE 201 HIHGLDKLQL211 AQFTITSYRF221 TTELMNFKSA231 GQFPRLSLHF241 HLRRNRGVYI 251 IQSYMPSVLL261 VAMSWVSFWI271 SQAAVPARVS281 LGITTVLTMT291 TLMVSARSSL 301 PRASAIKALD311 VYFWICYVFV321 FAALVEYAFA331 HFNADADTID428 IYARAVFPAA 438 FAAVNVIYWA448 AYA
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .OCT or .OCT2 or .OCT3 or :3OCT;style chemicals stick;color identity;select .E:249 or .E:252 or .E:256 or .E:312 or .E:316 or .E:442 or .E:445 or .E:446 or .E:449 or .E:450; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
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| REF 1 | Differential assembly diversifies GABA(A) receptor structures and signalling. Nature. 2022 Apr;604(7904):190-194. | ||||
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