Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T31992 | Target Info | |||
| Target Name | Carbonic anhydrase XIV (CA-XIV) | ||||
| Synonyms | UNQ690/PRO1335; Carbonic anhydrase 14; Carbonate dehydratase XIV | ||||
| Target Type | Successful Target | ||||
| Gene Name | CA14 | ||||
| Biochemical Class | Alpha-carbonic anhydrase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Acetazolamide | Ligand Info | |||||
| Structure Description | The crystal structure of the human carbonic anhydrase XIV | PDB:4LU3 | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [1] |
| PDB Sequence |
HWTYEGPHGQ
13 DHWPASYPEC23 GNNAQSPIDI33 QTDSVTFDPD43 LPALQPHGYD52 QPGTEPLDLH 60 NNGHTVQLSL70 PSTLYLGGLP85 RKYVAAQLHL95 HWGQKGSPGG104 SEHQINSEAT 114 FAELHIVHYD124 SDSYDSLSEA134 AERPQGLAVL144 GILIEVGETK153 NIAYEHILSH 163 LHEVRHKDQK173 TSVPPFNLRE183 LLPKQLGQYF192 RYNGSLTTPP202 CYQSVLWTVF 212 YRRSQISMEQ222 LEKLQGTLFS231 TEEEPSKLLV242 QNYRALQPLN252 QRMVFASFIQ 262 AGSSYT
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| Ligand Name: 4'-(4-Aminobenzoyl)biphenyl-4-Sulfonamide | Ligand Info | |||||
| Structure Description | The crystal structure of the human carbonic anhydrase XIV in complex with a 1,1'-biphenyl-4-sulfonamide inhibitor. | PDB:5CJF | ||||
| Method | X-ray diffraction | Resolution | 1.83 Å | Mutation | No | [2] |
| PDB Sequence |
HWTYEGPHGQ
13 DHWPASYPEC23 GNNAQSPIDI33 QTDSVTFDPD43 LPALQPHGYD52 QPGTEPLDLH 60 NNGHTVQLSL70 PSTLYLGGLP85 RKYVAAQLHL95 HWGQKGSPGG104 SEHQINSEAT 114 FAELHIVHYD124 SDSYDSLSEA134 AERPQGLAVL144 GILIEVGETK153 NIAYEHILSH 163 LHEVRHKDQK173 TSVPPFNLRE183 LLPKQLGQYF192 RYNGSLTTPP202 CYQSVLWTVF 212 YRRSQISMEQ222 LEKLQGTLFS231 TEEEPSKLLV242 QNYRALQPLN252 QRMVFASFIQ 262 AGSSYTT
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The structural comparison between membrane-associated human carbonic anhydrases provides insights into drug design of selective inhibitors. Biopolymers. 2014 Jul;101(7):769-78. | ||||
| REF 2 | Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors. J Med Chem. 2015 Nov 12;58(21):8564-72. | ||||
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