Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T33367 | Target Info | |||
| Target Name | Cytoplasmic aspartate aminotransferase (GOT1) | ||||
| Synonyms | Glutamate oxaloacetate transaminase-1; GOT1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | GOT1 | ||||
| Biochemical Class | Transaminase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Pyridoxal phosphate | Ligand Info | |||||
| Structure Description | Crystal structure of human Glutamate oxaloacetate transaminase 1 (GOT1) | PDB:3II0 | ||||
| Method | X-ray diffraction | Resolution | 2.05 Å | Mutation | No | [1] |
| PDB Sequence |
PVLVFKLTAD
24 FREDPDPRKV34 NLGVGAYRTD44 DCHPWVLPVV54 KKVEQKIAND64 NSLNHEYLPI 74 LGLAEFRSCA84 SRLALGDDSP94 ALKEKRVGGV104 QSLGGTGALR114 IGADFLARWY 124 NGTNNKNTPV134 YVSSPTWENH144 NAVFSAAGFK154 DIRSYRYWDA164 EKRGLDLQGF 174 LNDLENAPEF184 SIVVLHACAH194 NPTGIDPTPE204 QWKQIASVMK214 HRFLFPFFDS 224 AYQGFASGNL234 ERDAWAIRYF244 VSEGFEFFCA254 QSFSKNFGLY264 NERVGNLTVV 274 GKEPESILQV284 LSQMEKIVRI294 TWSNPPAQGA304 RIVASTLSNP314 ELFEEWTGNV 324 KTMADRILTM334 RSELRARLEA344 LKTPGTWNHI354 TDQIGMFSFT364 GLNPKQVEYL 374 VNEKHIYLLP384 SGRINVSGLT394 TKNLDYVATS404 IHEAVTKIAE414 NLYFQ |
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: (5E)-4-hydroxy-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-5-[[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]methylidene]furan-2-one | Ligand Info | |||||
| Structure Description | Crystal structure of human Glutamate oxaloacetate transaminase 1 (GOT1) in complex with AH | PDB:6LIG | ||||
| Method | X-ray diffraction | Resolution | 2.62 Å | Mutation | No | [2] |
| PDB Sequence |
PPSVFAEVPQ
12 AQPVLVFKLT22 ADFREDPDPR32 KVNLGVGAYR42 TDDCHPWVLP52 VVKKVEQKIA 62 NDNSLNHEYL72 PILGLAEFRS82 CASRLALGDD92 SPALKEKRVG102 GVQSLGGTGA 112 LRIGADFLAR122 WYNGTNNKNT132 PVYVSSPTWE142 NHNAVFSAAG152 FKDIRSYRYW 162 DAEKRGLDLQ172 GFLNDLENAP182 EFSIVVLHAC192 AHNPTGIDPT202 PEQWKQIASV 212 MKHRFLFPFF222 DSAYQGFASG232 NLERDAWAIR242 YFVSEGFEFF252 CAQSFSKNFG 262 LYNERVGNLT272 VVGKEPESIL282 QVLSQMEKIV292 RITWSNPPAQ302 GARIVASTLS 312 NPELFEEWTG322 NVKTMADRIL332 TMRSELRARL342 EALKTPGTWN352 HITDQIGMFS 362 FTGLNPKQVE372 YLVNEKHIYL382 LPSGRINVSG392 LTTKNLDYVA402 TSIHEAVTKI 412
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GLY39
3.204
GLY108
4.103
GLY109
3.161
THR110
3.076
LEU113
3.954
TRP141
2.680
HIS144
4.059
HIS190
4.385
ASN195
3.066
ASP223
2.948
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure of human Glutamate oxaloacetate transaminase 1 (GOT1) | ||||
| REF 2 | Crystal structure of human Glutamate oxaloacetate transaminase 1 (GOT1) in complex with AH | ||||
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