Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T33489 | Target Info | |||
| Target Name | Steryl-sulfatase (STS) | ||||
| Synonyms | Steryl-sulfate sulfohydrolase; Steroid sulfatase; STS; Estrone sulfatase; Arylsulfatase C; ASC | ||||
| Target Type | Successful Target | ||||
| Gene Name | STS | ||||
| Biochemical Class | Sulfuric ester hydrolase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: B-Octylglucoside | Ligand Info | |||||
| Structure Description | Structure of Human Placental Estrone/DHEA Sulfatase | PDB:1P49 | ||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | Yes | [1] |
| PDB Sequence |
AASRPNIILV
32 MADDLGIGDP42 GCYGNKTIRT52 PNIDRLASGG62 VKLTQHLAAS72 PLTPSRAAFM 83 TGRYPVRSGM93 ASWSRTGVFL103 FTASSGGLPT113 DEITFAKLLK123 DQGYSTALIG 133 KWHLGMSCHS143 KTDFCHHPLH153 HGFNYFYGIS163 LTNLRDCKPG173 EGSVFTTGFK 183 RLVFLPLQIV193 GVTLLTLAAL203 NCLGLLHVPL213 GVFFSLLFLA223 ALILTLFLGF 233 LHYFRPLNCF243 MMRNYEIIQQ253 PMSYDNLTQR263 LTVEAAQFIQ273 RNTETPFLLV 283 LSYLHVHTAL293 FSSKDFAGKS303 QHGVYGDAVE313 EMDWSVGQIL323 NLLDELRLAN 333 DTLIYFTSDQ343 GAHVEEVSSK353 GEIHGGSNGI363 YKGGKANNWE373 GGIRVPGILR 383 WPRVIQAGQK393 IDEPTSNMDI403 FPTVAKLAGA413 PLPEDRIIDG423 RDLMPLLEGK 433 SQRSDHEFLF443 HYCNAYLNAV453 RWHPQNSTSI463 WKAFFFTPNF473 NPVCFATHVC 487 FCFGSYVTHH497 DPPLLFDISK507 DPRERNPLTP517 ASEPRFYEIL527 KVMQEAADRH 537 TQTLPEVPDQ547 FSWNNFLWKP557 WLQLCCPSTG567 LSCQCDRE
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| Ligand Name: (3S)-3-(sulfooxy)-L-serine | Ligand Info | |||||
| Structure Description | Structure of Human Placental Estrone/DHEA Sulfatase | PDB:1P49 | ||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | Yes | [1] |
| PDB Sequence |
AASRPNIILV
32 MADDLGIGDP42 GCYGNKTIRT52 PNIDRLASGG62 VKLTQHLAAS72 PLTPSRAAFM 83 TGRYPVRSGM93 ASWSRTGVFL103 FTASSGGLPT113 DEITFAKLLK123 DQGYSTALIG 133 KWHLGMSCHS143 KTDFCHHPLH153 HGFNYFYGIS163 LTNLRDCKPG173 EGSVFTTGFK 183 RLVFLPLQIV193 GVTLLTLAAL203 NCLGLLHVPL213 GVFFSLLFLA223 ALILTLFLGF 233 LHYFRPLNCF243 MMRNYEIIQQ253 PMSYDNLTQR263 LTVEAAQFIQ273 RNTETPFLLV 283 LSYLHVHTAL293 FSSKDFAGKS303 QHGVYGDAVE313 EMDWSVGQIL323 NLLDELRLAN 333 DTLIYFTSDQ343 GAHVEEVSSK353 GEIHGGSNGI363 YKGGKANNWE373 GGIRVPGILR 383 WPRVIQAGQK393 IDEPTSNMDI403 FPTVAKLAGA413 PLPEDRIIDG423 RDLMPLLEGK 433 SQRSDHEFLF443 HYCNAYLNAV453 RWHPQNSTSI463 WKAFFFTPNF473 NPVCFATHVC 487 FCFGSYVTHH497 DPPLLFDISK507 DPRERNPLTP517 ASEPRFYEIL527 KVMQEAADRH 537 TQTLPEVPDQ547 FSWNNFLWKP557 WLQLCCPSTG567 LSCQCDRE
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of human estrone sulfatase suggests functional roles of membrane association. J Biol Chem. 2003 Jun 20;278(25):22989-97. | ||||
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