Binding Site Information of Target

Content Navigation (  All   None )                                      
Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T34318 Target Info
Target Name Cathelicidin antimicrobial peptide (CAMP)
Synonyms upregulating cAMP; hCAP18; CAP18; CAMP; Antibacterial protein LL37; 18 kDa cationic antimicrobial protein
Target Type Successful Target
Gene Name CAMP
Biochemical Class Cathelicidin family
UniProt ID
CAMP_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Lauryl Dimethylamine-N-Oxide Ligand Info
Structure Description The structure of LL-37 crystallized in the presence LDAO PDB:5NNK
Method X-ray diffraction Resolution 1.80 Å Mutation No [1]
PDB Sequence
LLGDFFRKSK
10
EKIGKEFKRI
20
VQRIKDFLRN
30
LVPR
Residue
Distance (Å)
LEU1
2.926
LEU2
3.091
ASP4
3.463
PHE5
2.212
PHE6
1.752
ARG7
3.126
LYS8
4.524
SER9
4.988
Residue
Distance (Å)
LYS10
2.356
GLU11
2.989
ILE13
2.395
GLY14
2.294
LYS15
4.463
PHE17
2.344
LYS18
2.435
Ligand Name: Dodecylphosphocholine Ligand Info
Structure Description The dimeric structure of LL-37 crystallized in DPC PDB:5NNT
Method X-ray diffraction Resolution 2.21 Å Mutation No [1]
PDB Sequence
LLGDFFRKSK
10
EKIGKEFKRI
20
VQRIKDFLRN
30
LVPR
Residue
Distance (Å)
LEU2
4.060
ASP4
3.296
PHE5
2.303
Residue
Distance (Å)
PHE6
1.791
ARG7
3.435
References  Top
REF 1 Structural remodeling and oligomerization of human cathelicidin on membranes suggest fibril-like structures as active species. Sci Rep. 2017 Nov 13;7(1):15371.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.