Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T36075 | Target Info | |||
| Target Name | Glucagon-like peptide 1 receptor (GLP1R) | ||||
| Synonyms | GLP-1R; GLP-1-R; GLP-1 receptor | ||||
| Target Type | Successful Target | ||||
| Gene Name | GLP1R | ||||
| Biochemical Class | GPCR secretin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: PF-06882961 | Ligand Info | |||||
| Structure Description | Non peptide agonist PF-06882961, bound to Glucagon-Like peptide-1 (GLP-1) Receptor | PDB:6X1A | ||||
| Method | Electron microscopy | Resolution | 2.50 Å | Mutation | No | [1] |
| PDB Sequence |
ATVSLWETVQ
37 KWREYRRQCQ47 RSLTEDPPPA57 TDLFCNRTFD67 EYACWPDGEP77 GSFVNVSCPW 87 YLPWASSVPQ97 GHVYRFCTAE107 GLWLQKDNSS117 LPWRDLSECE127 ESSPEEQLLF 143 LYIIYTVGYA153 LSFSALVIAS163 AILLGFRHLH173 CTRNYIHLNL183 FASFILRALS 193 VFIKDAALKW203 MYSTAAQQHQ213 WDGLLSYQDS223 LSCRLVFLLM233 QYCVAANYYW 243 LLVEGVYLYT253 LLAFSVFSEQ263 WIFRLYVSIG273 WGVPLLFVVP283 WGIVKYLYED 293 EGCWTRNSNM303 NYWLIIRLPI313 LFAIGVNFLI323 FVRVICIVVS333 KLKANLMCKT 343 DIKCRLAKST353 LTLIPLLGTH363 EVIFAFVMDE373 HARGTLRFIK383 LFTELSFTSF 393 QGLMVAILYC403 FVNNEVQLEF413 RKSWERWRLE423
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SER31
3.582
LEU32
3.570
TRP33
3.571
VAL36
3.614
GLN37
3.398
GLU138
4.582
LEU141
3.612
LYS197
3.076
LEU201
3.648
TRP203
3.307
SER206
3.569
THR207
3.696
LEU217
3.883
LEU218
4.002
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 3-Sulfinoalanine | Ligand Info | |||||
| Structure Description | Structure of the human GLP-1 receptor complex with PF-06372222 | PDB:5VEW | ||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | Yes | [2] |
| PDB Sequence |
SPEEQLLFLY
145 IIYTVGYALS155 FSALVIASAI165 LLGFRHLHCT175 RNYIHLNLFA185 SFILRALCVF 195 FKDAALKWLS219 YQDSLACRLV229 FLLQYCVAAN240 YYWLLVEGVY250 LYTLLAFNIF 1004 EMLRIDEGLR1014 LKIYKDTEGY1024 YTIGIGHLLT1034 KSPSLNAAKS1044 ELDKAIGRNT 1054 NGVITKDEAE1064 KLFNQDVDAA1074 VRGILRNAKL1084 KPVYDSLDAV1094 RRAALINMVF 1104 QMGETGVAGF1114 TNSLRMLQQK1124 RWDEAAVNLA1134 KSRWYNQTPN1144 RAKRVITTFR 1154 TGTWDAYSEQ263 WIFRLYVAIG273 WGVPLLFVVP283 WGIVKYLYED293 EGCWTRNSNM 303 NYWLIIRLPI313 LFACIVNFLI323 FVRVICIVVS333 KLKANLMCKT343 DIAFRLAKST 353 LTLIPLLCTH363 EVIFAFVMDR380 FIKLFTELSF390 TSFQGLMVAI400 LYCFVNNEVQ 410 LEFRKSWERW420 RL
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Oleic acid | Ligand Info | |||||
| Structure Description | Structure of the human GLP-1 receptor complex with PF-06372222 | PDB:5VEW | ||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | Yes | [2] |
| PDB Sequence |
SPEEQLLFLY
145 IIYTVGYALS155 FSALVIASAI165 LLGFRHLHCT175 RNYIHLNLFA185 SFILRALCVF 195 FKDAALKWLS219 YQDSLACRLV229 FLLQYCVAAN240 YYWLLVEGVY250 LYTLLAFNIF 1004 EMLRIDEGLR1014 LKIYKDTEGY1024 YTIGIGHLLT1034 KSPSLNAAKS1044 ELDKAIGRNT 1054 NGVITKDEAE1064 KLFNQDVDAA1074 VRGILRNAKL1084 KPVYDSLDAV1094 RRAALINMVF 1104 QMGETGVAGF1114 TNSLRMLQQK1124 RWDEAAVNLA1134 KSRWYNQTPN1144 RAKRVITTFR 1154 TGTWDAYSEQ263 WIFRLYVAIG273 WGVPLLFVVP283 WGIVKYLYED293 EGCWTRNSNM 303 NYWLIIRLPI313 LFACIVNFLI323 FVRVICIVVS333 KLKANLMCKT343 DIAFRLAKST 353 LTLIPLLCTH363 EVIFAFVMDR380 FIKLFTELSF390 TSFQGLMVAI400 LYCFVNNEVQ 410 LEFRKSWERW420 RL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .OLA or .OLA2 or .OLA3 or :3OLA;style chemicals stick;color identity;select .A:167 or .A:173; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | Cryo-EM structure of the compound 2 and GLP-1-bound human GLP-1 receptor-Gs complex | PDB:7DUQ | ||||
| Method | Electron microscopy | Resolution | 2.50 Å | Mutation | Yes | [3] |
| PDB Sequence |
TVSLWETVQK
38 WREYRRQCQR48 SLTEDPPPAT58 DLFCNRTFDE68 YACWPDGEPG78 SFVNVSCPWY 88 LPWASSVPQG98 HVYRFCTAEG108 LWLQKDNSSL118 PWRDLSECEE128 SSPEEQLLFL 144 YIIYTVGYAL154 SFSALVIASA164 ILLGFRHLHC174 TRNYIHLNLF184 ASFILRALSV 194 FIKDAALKWM204 YSTAAQQHQW214 DGLLSYQDSL224 SCRLVFLLMQ234 YCVAANYYWL 244 LVEGVYLYTL254 LAFSVLSEQW264 IFRLYVSIGW274 GVPLLFVVPW284 GIVKYLYEDE 294 GCWTRNSNMN304 YWLIIRLPIL314 FAIGVNFLIF324 VRVICIVVSK334 LKANDIKCRL 349 AKSTLTLIPL359 LGTHEVIFAF369 VMDEHARGTL379 RFIKLFTELS389 FTSFQGLMVA 399 ILYCFVNNEV409 QLEFRKSWER419 WRLE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CLR or .CLR2 or .CLR3 or :3CLR;style chemicals stick;color identity;select .R:145 or .R:149 or .R:153 or .R:154 or .R:156 or .R:157 or .R:158 or .R:160 or .R:161 or .R:165 or .R:182 or .R:195 or .R:266 or .R:267 or .R:270 or .R:271 or .R:274 or .R:275 or .R:278 or .R:321 or .R:324 or .R:325 or .R:328 or .R:329 or .R:332 or .R:336 or .R:346 or .R:349 or .R:350 or .R:353 or .R:354 or .R:357 or .R:362 or .R:363 or .R:365 or .R:366 or .R:390 or .R:396 or .R:400 or .R:404 or .R:405 or .R:410 or .R:413 or .R:414; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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TYR145
3.283
THR149
3.480
ALA153
3.970
LEU154
3.780
PHE156
3.537
SER157
3.259
ALA158
3.916
VAL160
3.950
ILE161
3.559
ILE165
4.953
ASN182
4.937
PHE195
3.554
PHE266
4.422
ARG267
3.792
VAL270
4.221
SER271
4.626
TRP274
3.919
GLY275
4.359
LEU278
3.906
PHE321
3.587
PHE324
4.098
VAL325
4.224
ILE328
3.881
CYS329
4.147
VAL332
3.888
LYS336
3.192
LYS346
3.532
LEU349
3.831
ALA350
3.542
THR353
4.411
LEU354
3.696
ILE357
3.758
THR362
3.573
HIS363
4.215
VAL365
3.587
ILE366
3.718
PHE390
4.194
LEU396
3.656
ILE400
3.689
PHE404
3.448
VAL405
3.793
GLN410
3.439
PHE413
3.459
ARG414
4.142
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Alpha-Aminoisobutyric Acid | Ligand Info | |||||
| Structure Description | Semaglutide-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in Complex with Gs protein | PDB:7KI0 | ||||
| Method | Electron microscopy | Resolution | 2.50 Å | Mutation | No | [4] |
| PDB Sequence |
TVSLWETVQK
38 WREYRRQCQR48 SLTEDPPPAT58 DLFCNRTFDE68 YACWPDGEPG78 SFVNVSCPWY 88 LPWASSVPQG98 HVYRFCTAEG108 LWLQKDNSSL118 PWRDLSECEE128 SPEEQLLFLY 145 IIYTVGYALS155 FSALVIASAI165 LLGFRHLHCT175 RNYIHLNLFA185 SFILRALSVF 195 IKDAALKWMY205 STAAQQHQWD215 GLLSYQDSLS225 CRLVFLLMQY235 CVAANYYWLL 245 VEGVYLYTLL255 AFSVFSEQWI265 FRLYVSIGWG275 VPLLFVVPWG285 IVKYLYEDEG 295 CWTRNSNMNY305 WLIIRLPILF315 AIGVNFLIFV325 RVICIVVSKL335 KANLDIKCRL 349 AKSTLTLIPL359 LGTHEVIFAF369 VMDEHARGTL379 RFIKLFTELS389 FTSFQGLMVA 399 ILYCFVNNEV409 QLEFRKSWER419 WRLE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .AIB or .AIB2 or .AIB3 or :3AIB;style chemicals stick;color identity;select .R:241 or .R:383 or .R:384 or .R:387 or .R:388; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: N-{4-[(R)-(3,3-Dimethylcyclobutyl)({6-[4-(Trifluoromethyl)-1h-Imidazol-1-Yl]pyridin-3-Yl}amino)methyl]benzene-1-Carbonyl}-Beta-Alanine | Ligand Info | |||||
| Structure Description | Structure of the human GLP-1 receptor complex with PF-06372222 | PDB:5VEW | ||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | Yes | [2] |
| PDB Sequence |
SPEEQLLFLY
145 IIYTVGYALS155 FSALVIASAI165 LLGFRHLHCT175 RNYIHLNLFA185 SFILRALCVF 195 FKDAALKWLS219 YQDSLACRLV229 FLLQYCVAAN240 YYWLLVEGVY250 LYTLLAFNIF 1004 EMLRIDEGLR1014 LKIYKDTEGY1024 YTIGIGHLLT1034 KSPSLNAAKS1044 ELDKAIGRNT 1054 NGVITKDEAE1064 KLFNQDVDAA1074 VRGILRNAKL1084 KPVYDSLDAV1094 RRAALINMVF 1104 QMGETGVAGF1114 TNSLRMLQQK1124 RWDEAAVNLA1134 KSRWYNQTPN1144 RAKRVITTFR 1154 TGTWDAYSEQ263 WIFRLYVAIG273 WGVPLLFVVP283 WGIVKYLYED293 EGCWTRNSNM 303 NYWLIIRLPI313 LFACIVNFLI323 FVRVICIVVS333 KLKANLMCKT343 DIAFRLAKST 353 LTLIPLLCTH363 EVIFAFVMDR380 FIKLFTELSF390 TSFQGLMVAI400 LYCFVNNEVQ 410 LEFRKSWERW420 RL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .97Y or .97Y2 or .97Y3 or :397Y;style chemicals stick;color identity;select .A:328 or .A:331 or .A:332 or .A:335 or .A:342 or .A:347 or .A:348 or .A:349 or .A:351 or .A:352 or .A:354 or .A:355 or .A:397 or .A:401 or .A:402 or .A:405 or .A:406 or .A:407 or .A:408; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-{[(4-Cyclohexylphenyl){[3-(Methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1h-Tetrazol-5-Yl)benzamide | Ligand Info | |||||
| Structure Description | Structure of the human GLP-1 receptor complex with NNC0640 | PDB:5VEX | ||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | Yes | [2] |
| PDB Sequence |
SPEEQLLFLY
145 IIYTVGYALS155 FSALVIASAI165 LLGFRHLHCT175 RNYIHLNLFA185 SFILRALCVF 195 FKDAALKWLS219 YQDSLACRLV229 FLLQYCVAAN240 YYWLLVEGVY250 LYTLLAFNIF 1004 EMLRIDEGLR1014 LKIYKDTEGY1024 YTIGIGHLLT1034 KSPSLNAAKS1044 ELDKAIGRNT 1054 NGVITKDEAE1064 KLFNQDVDAA1074 VRGILRNAKL1084 KPVYDSLDAV1094 RRAALINMVF 1104 QMGETGVAGF1114 TNSLRMLQQK1124 RWDEAAVNLA1134 KSRWYNQTPN1144 RAKRVITTFR 1154 TGTWDAYSEQ263 WIFRLYVAIG273 WGVPLLFVVP283 WGIVKYLYED293 EGCWTRNSNM 303 NYWLIIRLPI313 LFACIVNFLI323 FVRVICIVVS333 KLKANLMCKT343 DIAFRLAKST 353 LTLIPLLCTH363 EVIFAFVMDR380 FIKLFTELSF390 TSFQGLMVAI400 LYCFVNNEVQ 410 LEFRKSWERW420 RL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .97V or .97V2 or .97V3 or :397V;style chemicals stick;color identity;select .A:324 or .A:331 or .A:347 or .A:348 or .A:349 or .A:350 or .A:351 or .A:352 or .A:354 or .A:355 or .A:359 or .A:397 or .A:401 or .A:405 or .A:406 or .A:407 or .A:408; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 1-[(1R)-1-(2,6-dichloro-3-methoxyphenyl)ethyl]-6-{2-[(2R)-piperidin-2-yl]phenyl}-1H-benzimidazole | Ligand Info | |||||
| Structure Description | Cryo-EM structure of the Glucagon-like peptide-1 receptor in complex with G protein, GLP-1 peptide and a positive allosteric modulator | PDB:6VCB | ||||
| Method | Electron microscopy | Resolution | 3.30 Å | Mutation | Yes | [5] |
| PDB Sequence |
TVSLWETVQK
38 WREYRRQCQR48 SLTEDPPPFC62 NRTFDEYACW72 PDGEPGSFVN82 VSCPWYLPWA 92 SSVPQGHVYR102 FCTAEGLWLQ112 KDNSSLPWRD122 LSECEESPEE139 QLLFLYIIYT 149 VGYALSFSAL159 VIASAILLGF169 RHLHCTRNYI179 HLNLFASFIL189 RALSVFIKDA 199 ALKWMYSTAA209 QQHQWDGLLS219 YQDSLSCRLV229 FLLMQYCVAA239 NYYWLLVEGV 249 YLYTLLAFSV259 FSEQWIFRLY269 VSIGWGVPLL279 FVVPWGIVKY289 LYEDEGCWTR 299 NSNMNYWLII309 RLPILFAIGV319 NFLIFVRVIC329 IVVSKLKANL339 DIKCRLAKST 353 LTLIPLLGTH363 EVIFAFVMDE373 HARGTLRFIK383 LFTELSFTSF393 QGLMVAILYC 403 FVNNEVQLEF413 RKSWERWR
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .QW7 or .QW72 or .QW73 or :3QW7;style chemicals stick;color identity;select .R:138 or .R:141 or .R:142 or .R:145 or .R:146 or .R:198 or .R:199 or .R:201 or .R:202 or .R:205 or .R:206; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-(tert-butylamino)-6,7-dichloro-1H-quinoxaline-2-thione | Ligand Info | |||||
| Structure Description | Cryo-EM structure of the compound 2 and GLP-1-bound human GLP-1 receptor-Gs complex | PDB:7DUQ | ||||
| Method | Electron microscopy | Resolution | 2.50 Å | Mutation | Yes | [3] |
| PDB Sequence |
TVSLWETVQK
38 WREYRRQCQR48 SLTEDPPPAT58 DLFCNRTFDE68 YACWPDGEPG78 SFVNVSCPWY 88 LPWASSVPQG98 HVYRFCTAEG108 LWLQKDNSSL118 PWRDLSECEE128 SSPEEQLLFL 144 YIIYTVGYAL154 SFSALVIASA164 ILLGFRHLHC174 TRNYIHLNLF184 ASFILRALSV 194 FIKDAALKWM204 YSTAAQQHQW214 DGLLSYQDSL224 SCRLVFLLMQ234 YCVAANYYWL 244 LVEGVYLYTL254 LAFSVLSEQW264 IFRLYVSIGW274 GVPLLFVVPW284 GIVKYLYEDE 294 GCWTRNSNMN304 YWLIIRLPIL314 FAIGVNFLIF324 VRVICIVVSK334 LKANDIKCRL 349 AKSTLTLIPL359 LGTHEVIFAF369 VMDEHARGTL379 RFIKLFTELS389 FTSFQGLMVA 399 ILYCFVNNEV409 QLEFRKSWER419 WRLE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .HNO or .HNO2 or .HNO3 or :3HNO;style chemicals stick;color identity;select .R:346 or .R:347 or .R:350 or .R:351 or .R:354; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 1,3-Bis(4-(tert-butoxycarbonyl)benzamido)-2,4-bis(3-methoxy-4-(thiophene-2-carbonyloxy)phenyl)cyclobutane-1,3-dicarboxylic acid | Ligand Info | |||||
| Structure Description | Cryo-EM structure of the Boc5-bound hGLP-1R-Gs complex | PDB:7X8R | ||||
| Method | Electron microscopy | Resolution | 2.61 Å | Mutation | Yes | [6] |
| PDB Sequence |
SLWETVQKWR
40 EYRRQCQRSL50 TEDPPEEQLL142 FLYIIYTVGY152 ALSFSALVIA162 SAILLGFRHL 172 HCTRNYIHLN182 LFASFILRAL192 SVFIKDAALK202 WMYSTAAQQH212 QWDGLLSYQD 222 SLSCRLVFLL232 MQYCVAANYY242 WLLVEGVYLY252 TLLAFSVFSE262 QWIFRLYVSI 272 GWGVPLLFVV282 PWGIVKYLYE292 DEGCWTRNSN302 MNYWLIIRLP312 ILFAIGVNFL 322 IFVRVICIVV332 SKLKANDIKC347 RLAKSTLTLI357 PLLGTHEVIF367 AFTLRFIKLF 385 TELSFTSFQG395 LMVAILYCFV405 NNEVQLEFRK415 SWERWRLE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .BYI or .BYI2 or .BYI3 or :3BYI;style chemicals stick;color identity;select .R:31 or .R:32 or .R:33 or .R:137 or .R:140 or .R:141 or .R:144 or .R:145 or .R:148 or .R:152 or .R:190 or .R:194 or .R:196 or .R:197 or .R:198 or .R:200 or .R:201 or .R:202 or .R:205 or .R:226 or .R:229 or .R:230 or .R:233 or .R:296 or .R:298 or .R:299 or .R:380 or .R:381 or .R:384 or .R:388; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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SER31
3.995
LEU32
4.748
TRP33
3.390
PRO137
4.030
GLN140
3.162
LEU141
3.152
LEU144
3.326
TYR145
4.530
TYR148
4.254
TYR152
4.052
ARG190
4.856
VAL194
3.906
ILE196
4.618
LYS197
3.513
ASP198
4.620
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| Ligand Name: 3-[(1S,2S)-1-[5-[(4S)-2,2-dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one | Ligand Info | |||||
| Structure Description | Compound2_GLP-1R_OWL833_Gs complex structure | PDB:7E14 | ||||
| Method | Electron microscopy | Resolution | 2.90 Å | Mutation | No | [3] |
| PDB Sequence |
TVSLWETVQK
38 WREYRRQCQR48 SLTEDPPPAT58 DLFCNRTFDE68 YACWPDGEPG78 SFVNVSCPWY 88 LPWASSVPQG98 HVYRFCTAEG108 LWLQKDNSSL118 PWRDLSECEE128 SSPEEQLLFL 144 YIIYTVGYAL154 SFSALVIASA164 ILLGFRHLHC174 TRNYIHLNLF184 ASFILRALSV 194 FIKDAALKWM204 YSTAAQQHQW214 DGLLSYQDSL224 SCRLVFLLMQ234 YCVAANYYWL 244 LVEGVYLYTL254 LAFSVLSEQW264 IFRLYVSIGW274 GVPLLFVVPW284 GIVKYLYEDE 294 GCWTRNSNMN304 YWLIIRLPIL314 FAIGVNFLIF324 VRVICIVVSK334 LKADIKCRLA 350 KSTLTLIPLL360 GTHEVIFAGT378 LRFIKLFTEL388 SFTSFQGLMV398 AILYCFVNNE 408 VQLEFRKSWE418 RWRLE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .V6G or .V6G2 or .V6G3 or :3V6G;style chemicals stick;color identity;select .R:31 or .R:33 or .R:34 or .R:137 or .R:138 or .R:141 or .R:142 or .R:144 or .R:145 or .R:148 or .R:196 or .R:197 or .R:198 or .R:200 or .R:201 or .R:202 or .R:204 or .R:205 or .R:220 or .R:226 or .R:229 or .R:230 or .R:233 or .R:234 or .R:296 or .R:298 or .R:380 or .R:384 or .R:388; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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SER31
3.162
TRP33
4.100
GLU34
3.380
PRO137
3.413
GLU138
3.546
LEU141
3.398
LEU142
4.948
LEU144
3.296
TYR145
3.169
TYR148
3.069
ILE196
4.631
LYS197
3.032
ASP198
2.740
ALA200
3.735
LEU201
3.745
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Palmitoyl glutamic acid | Ligand Info | |||||
| Structure Description | Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GLP-1R-Gs complex | PDB:7VBH | ||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | Yes | [7] |
| PDB Sequence |
ATVSLWETVQ
37 KWREYRRQCQ47 RSLTEDPPPA57 TDLFCNRTFD67 EYACWPDGEP77 GSFVNVSCPW 87 YLPWASSVPQ97 GHVYRFCTAE107 GLWLQKDNSS117 LPWRDLSECE127 ESEEQLLFLY 145 IIYTVGYALS155 FSALVIASAI165 LLGFRHLHCT175 RNYIHLNLFA185 SFILRALSVF 195 IKDAALKWMY205 STAAQQHQWD215 GLLSYQDSLS225 CRLVFLLMQY235 CVAANYYWLL 245 VEGVYLYTLL255 AFSVLSEQWI265 FRLYVSIGWG275 VPLLFVVPWG285 IVKYLYEDEG 295 CWTRNSNMNY305 WLIIRLPILF315 AIGVNFLIFV325 RVICIVVSKL335 KADIKCRLAK 351 STLTLIPLLG361 THEVIFAFVM371 DEHARGTLRF381 IKLFTELSFT391 SFQGLMVAIL 401 YCFVNNEVQL411 EFRKSWERWR421 LE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .D6M or .D6M2 or .D6M3 or :3D6M;style chemicals stick;color identity;select .R:138 or .R:141 or .R:142 or .R:145 or .R:146 or .R:149 or .R:150 or .R:153 or .R:154 or .R:157 or .R:198 or .R:201 or .R:202; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2,4-Bis(3-methoxy-4-thiophen-2-ylcarbonyloxy-phenyl)-1,3-bis[[4-(2-methylpropanoylamino)phenyl]carbonylamino]cyclobutane-1,3-dicarboxylic acid | Ligand Info | |||||
| Structure Description | Cryo-EM structure of the WB4-24-bound hGLP-1R-Gs complex | PDB:7X8S | ||||
| Method | Electron microscopy | Resolution | 3.09 Å | Mutation | Yes | [6] |
| PDB Sequence |
SLWETVQKWR
40 EYRRQCQRSL50 TEDPEEQLLF143 LYIIYTVGYA153 LSFSALVIAS163 AILLGFRHLH 173 CTRNYIHLNL183 FASFILRALS193 VFIKDAALKW203 MYSTAAQQHQ213 WDGLLSYQDS 223 LSCRLVFLLM233 QYCVAANYYW243 LLVEGVYLYT253 LLAFSVFSEQ263 WIFRLYVSIG 273 WGVPLLFVVP283 WGIVKYLYED293 EGCWTRNSNM303 NYWLIIRLPI313 LFAIGVNFLI 323 FVRVICIVVS333 KLKANDIKCR348 LAKSTLTLIP358 LLGTHEVIFA368 FVGTLRFIKL 384 FTELSFTSFQ394 GLMVAILYCF404 VNNEVQLEFR414 KSWERWRLE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .WB2 or .WB22 or .WB23 or :3WB2;style chemicals stick;color identity;select .R:31 or .R:33 or .R:138 or .R:140 or .R:141 or .R:144 or .R:145 or .R:148 or .R:152 or .R:194 or .R:197 or .R:198 or .R:201 or .R:202 or .R:204 or .R:226 or .R:229 or .R:230 or .R:296 or .R:298 or .R:299 or .R:380 or .R:381 or .R:384 or .R:385 or .R:388; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER31
4.523
TRP33
3.156
GLU138
4.703
GLN140
2.812
LEU141
3.197
LEU144
3.611
TYR145
3.813
TYR148
4.057
TYR152
3.977
VAL194
3.947
LYS197
3.183
ASP198
3.693
LEU201
3.733
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| Ligand Name: 3-[(1S)-1-[5-(2,2-dimethylmorpholin-4-yl)-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]indol-1-yl]butyl]-4H-1,2,4-oxadiazol-5-one | Ligand Info | |||||
| Structure Description | Non peptide agonist CHU-128, bound to Glucagon-Like peptide-1 (GLP-1) Receptor | PDB:6X19 | ||||
| Method | Electron microscopy | Resolution | 2.10 Å | Mutation | No | [1] |
| PDB Sequence |
TVSLWETVQK
38 WREYRRQCQR48 SLTEDPPPAT58 DLFCNRTFDE68 YACWPDGEPG78 SFVNVSCPWY 88 LPWASSVPQG98 HVYRFCTAEG108 LWLQKDNSSL118 PWRDLSECEE128 SSSPEEQLLF 143 LYIIYTVGYA153 LSFSALVIAS163 AILLGFRHLH173 CTRNYIHLNL183 FASFILRALS 193 VFIKDAALKW203 MYSTAAQQHQ213 WDGLLSYQDS223 LSCRLVFLLM233 QYCVAANYYW 243 LLVEGVYLYT253 LLAFSVFSEQ263 WIFRLYVSIG273 WGVPLLFVVP283 WGIVKYLYED 293 EGCWTRNSNM303 NYWLIIRLPI313 LFAIGVNFLI323 FVRVICIVVS333 KLKANLMCKT 343 DIKCRLAKST353 LTLIPLLGTH363 EVIFAFVMDE373 HTLRFIKLFT386 ELSFTSFQGL 396 MVAILYCFVN406 NEVQLEFRKS416 WERWRLE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .UK1 or .UK12 or .UK13 or :3UK1;style chemicals stick;color identity;select .R:31 or .R:33 or .R:34 or .R:137 or .R:138 or .R:141 or .R:142 or .R:144 or .R:145 or .R:148 or .R:197 or .R:198 or .R:200 or .R:201 or .R:202 or .R:204 or .R:205 or .R:220 or .R:225 or .R:226 or .R:229 or .R:230 or .R:233 or .R:296 or .R:298 or .R:300 or .R:384 or .R:388; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER31
3.259
TRP33
3.277
GLU34
3.179
PRO137
3.584
GLU138
3.382
LEU141
3.262
LEU142
4.925
LEU144
3.252
TYR145
3.427
TYR148
3.563
LYS197
3.209
ASP198
3.257
ALA200
4.252
LEU201
3.498
|
|||||
| Ligand Name: 2-[2-[2-[[2-[2-(2-Aminoethoxy)ethoxy]acetyl]amino]ethoxy]ethoxy]acetic acid | Ligand Info | |||||
| Structure Description | Semaglutide-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in Complex with Gs protein | PDB:7KI0 | ||||
| Method | Electron microscopy | Resolution | 2.50 Å | Mutation | No | [4] |
| PDB Sequence |
TVSLWETVQK
38 WREYRRQCQR48 SLTEDPPPAT58 DLFCNRTFDE68 YACWPDGEPG78 SFVNVSCPWY 88 LPWASSVPQG98 HVYRFCTAEG108 LWLQKDNSSL118 PWRDLSECEE128 SPEEQLLFLY 145 IIYTVGYALS155 FSALVIASAI165 LLGFRHLHCT175 RNYIHLNLFA185 SFILRALSVF 195 IKDAALKWMY205 STAAQQHQWD215 GLLSYQDSLS225 CRLVFLLMQY235 CVAANYYWLL 245 VEGVYLYTLL255 AFSVFSEQWI265 FRLYVSIGWG275 VPLLFVVPWG285 IVKYLYEDEG 295 CWTRNSNMNY305 WLIIRLPILF315 AIGVNFLIFV325 RVICIVVSKL335 KANLDIKCRL 349 AKSTLTLIPL359 LGTHEVIFAF369 VMDEHARGTL379 RFIKLFTELS389 FTSFQGLMVA 399 ILYCFVNNEV409 QLEFRKSWER419 WRLE
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .WF1 or .WF12 or .WF13 or :3WF1;style chemicals stick;color identity;select .R:137 or .R:138; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| Ligand Name: 2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid | Ligand Info | |||||
| Structure Description | GLP-1R-Gs complex structure with a small molecule full agonist | PDB:7C2E | ||||
| Method | Electron microscopy | Resolution | 4.20 Å | Mutation | No | [8] |
| PDB Sequence |
VSLWETVQKW
39 REYRRQCQRS49 LTEDPPPATD59 LFCNRTFDEY69 ACWPDGEPGS79 FVNVSCPWYL 89 PWASSVPQGH99 VYRFCTAEGL109 WLQKDNSSLP119 WRDLSECEEP137 EEQLLFLYII 147 YTVGYALSFS157 ALVIASAILL167 GFRHLHCTRN177 YIHLNLFASF187 ILRALSVFIK 197 DAALKWMYST207 AAQQHQWDGL217 LSYQDSLSCR227 LVFLLMQYCV237 AANYYWLLVE 247 GVYLYTLLAF257 SVFSEQWIFR267 LYVSIGWGVP277 LLFVVPWGIV287 KYLYEDEGCW 297 TRNSNMNYWL307 IIRLPILFAI317 GVNFLIFVRV327 ICIVVSKLKA337 DIKCRLAKST 353 LTLIPLLGTH363 EVIFAFVMDE373 HARGTLRFIK383 LFTELSFTSF393 QGLMVAILYC 403 FVNNEVQLEF413 RKSWERWRLE423
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FFR or .FFR2 or .FFR3 or :3FFR;style chemicals stick;color identity;select .R:32 or .R:33 or .R:36 or .R:37 or .R:138 or .R:141 or .R:197 or .R:201 or .R:204 or .R:205 or .R:218 or .R:222 or .R:226 or .R:230 or .R:296 or .R:297 or .R:298 or .R:380 or .R:381 or .R:384 or .R:385; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
LEU32
3.012
TRP33
3.494
VAL36
3.101
GLN37
2.773
GLU138
4.175
LEU141
3.614
LYS197
3.619
LEU201
3.783
MET204
3.841
TYR205
4.238
LEU218
3.144
|
|||||
| Ligand Name: (2~{S})-2-azanyl-3-(1~{H}-1,2,3,4-tetrazol-5-yl)propanoic acid | Ligand Info | |||||
| Structure Description | Crystal structure of thermostabilised full-length GLP-1R in complex with a truncated peptide agonist at 3.7 A resolution | PDB:5NX2 | ||||
| Method | X-ray diffraction | Resolution | 3.70 Å | Mutation | Yes | [9] |
| PDB Sequence |
TVSLWETVQK
38 WREYRRQCQR48 SLTEDPPPAT58 DLFCNRTFDE68 YACWPDGEPG78 SFVNVSCPWY 88 LPWASSVPQG98 HVYRFCTAEG108 LWLQKDNSSL118 PWRDLSECEE128 SKRGERSSPE 138 EQLLFLYIIY148 TVGYALSFSA158 LVIASAILLG168 FRHLHCTRNY178 IHLNLFASFI 188 LRALSVFIKD198 AALKWMYSEA208 AQAHQWRGLL218 SYQDSLSCRL228 VFLFMQYCVA 238 ANYYWLLVEG248 VYLYTLLAFS258 VFSEQWIFRL268 YVSIGWGVPL278 LFVVPWGIVK 288 YLYEDEACWA298 RNSNMNYWLI308 IRLPILFAIG318 VNFLIFVRVI328 AIVVSKLKAN 338 LMCKTDIKCR348 LAKSTLTLIA358 LLATVEVIFA368 FVMDEHARGT378 LRFIKLFTEL 388 SFTSFQGLMV398 AILYCFANNE408 VQLEFRKSW
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .9DQ or .9DQ2 or .9DQ3 or :39DQ;style chemicals stick;color identity;select .A:152 or .A:190 or .A:194 or .A:197 or .A:233 or .A:237 or .A:388 or .A:391; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: (2~{S})-2-azanyl-5-(3,5-dimethylphenyl)pentanamide | Ligand Info | |||||
| Structure Description | Crystal structure of thermostabilised full-length GLP-1R in complex with a truncated peptide agonist at 3.7 A resolution | PDB:5NX2 | ||||
| Method | X-ray diffraction | Resolution | 3.70 Å | Mutation | Yes | [9] |
| PDB Sequence |
TVSLWETVQK
38 WREYRRQCQR48 SLTEDPPPAT58 DLFCNRTFDE68 YACWPDGEPG78 SFVNVSCPWY 88 LPWASSVPQG98 HVYRFCTAEG108 LWLQKDNSSL118 PWRDLSECEE128 SKRGERSSPE 138 EQLLFLYIIY148 TVGYALSFSA158 LVIASAILLG168 FRHLHCTRNY178 IHLNLFASFI 188 LRALSVFIKD198 AALKWMYSEA208 AQAHQWRGLL218 SYQDSLSCRL228 VFLFMQYCVA 238 ANYYWLLVEG248 VYLYTLLAFS258 VFSEQWIFRL268 YVSIGWGVPL278 LFVVPWGIVK 288 YLYEDEACWA298 RNSNMNYWLI308 IRLPILFAIG318 VNFLIFVRVI328 AIVVSKLKAN 338 LMCKTDIKCR348 LAKSTLTLIA358 LLATVEVIFA368 FVMDEHARGT378 LRFIKLFTEL 388 SFTSFQGLMV398 AILYCFANNE408 VQLEFRKSW
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .9DZ or .9DZ2 or .9DZ3 or :39DZ;style chemicals stick;color identity;select .A:31 or .A:32 or .A:33 or .A:34 or .A:36 or .A:201 or .A:204 or .A:205 or .A:217 or .A:221 or .A:294 or .A:295 or .A:296 or .A:298 or .A:299; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| Ligand Name: 2-Hydroxymethyl-6-octylsulfanyl-tetrahydro-pyran-3,4,5-triol | Ligand Info | |||||
| Structure Description | Crystal structure of thermostabilised full-length GLP-1R in complex with a truncated peptide agonist at 3.7 A resolution | PDB:5NX2 | ||||
| Method | X-ray diffraction | Resolution | 3.70 Å | Mutation | Yes | [9] |
| PDB Sequence |
TVSLWETVQK
38 WREYRRQCQR48 SLTEDPPPAT58 DLFCNRTFDE68 YACWPDGEPG78 SFVNVSCPWY 88 LPWASSVPQG98 HVYRFCTAEG108 LWLQKDNSSL118 PWRDLSECEE128 SKRGERSSPE 138 EQLLFLYIIY148 TVGYALSFSA158 LVIASAILLG168 FRHLHCTRNY178 IHLNLFASFI 188 LRALSVFIKD198 AALKWMYSEA208 AQAHQWRGLL218 SYQDSLSCRL228 VFLFMQYCVA 238 ANYYWLLVEG248 VYLYTLLAFS258 VFSEQWIFRL268 YVSIGWGVPL278 LFVVPWGIVK 288 YLYEDEACWA298 RNSNMNYWLI308 IRLPILFAIG318 VNFLIFVRVI328 AIVVSKLKAN 338 LMCKTDIKCR348 LAKSTLTLIA358 LLATVEVIFA368 FVMDEHARGT378 LRFIKLFTEL 388 SFTSFQGLMV398 AILYCFANNE408 VQLEFRKSW
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SOG or .SOG2 or .SOG3 or :3SOG;style chemicals stick;color identity;select .A:29 or .A:138 or .A:139 or .A:140 or .A:342 or .A:346 or .A:377 or .A:378 or .A:380 or .A:381 or .A:405 or .A:407 or .A:410 or .A:414; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: 3-[2-(1~{H}-imidazol-4-yl)ethylamino]-2,2-dimethyl-3-oxidanylidene-propanoic acid | Ligand Info | |||||
| Structure Description | Crystal structure of thermostabilised full-length GLP-1R in complex with a truncated peptide agonist at 3.7 A resolution | PDB:5NX2 | ||||
| Method | X-ray diffraction | Resolution | 3.70 Å | Mutation | Yes | [9] |
| PDB Sequence |
TVSLWETVQK
38 WREYRRQCQR48 SLTEDPPPAT58 DLFCNRTFDE68 YACWPDGEPG78 SFVNVSCPWY 88 LPWASSVPQG98 HVYRFCTAEG108 LWLQKDNSSL118 PWRDLSECEE128 SKRGERSSPE 138 EQLLFLYIIY148 TVGYALSFSA158 LVIASAILLG168 FRHLHCTRNY178 IHLNLFASFI 188 LRALSVFIKD198 AALKWMYSEA208 AQAHQWRGLL218 SYQDSLSCRL228 VFLFMQYCVA 238 ANYYWLLVEG248 VYLYTLLAFS258 VFSEQWIFRL268 YVSIGWGVPL278 LFVVPWGIVK 288 YLYEDEACWA298 RNSNMNYWLI308 IRLPILFAIG318 VNFLIFVRVI328 AIVVSKLKAN 338 LMCKTDIKCR348 LAKSTLTLIA358 LLATVEVIFA368 FVMDEHARGT378 LRFIKLFTEL 388 SFTSFQGLMV398 AILYCFANNE408 VQLEFRKSW
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .9DK or .9DK2 or .9DK3 or :39DK;style chemicals stick;color identity;select .A:190 or .A:237 or .A:241 or .A:306 or .A:310 or .A:313 or .A:314 or .A:365 or .A:368 or .A:383 or .A:384 or .A:387 or .A:388 or .A:391; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: Unii-8rop77VW1I | Ligand Info | |||||
| Structure Description | Crystal structure of thermostabilised full-length GLP-1R in complex with a truncated peptide agonist at 3.7 A resolution | PDB:5NX2 | ||||
| Method | X-ray diffraction | Resolution | 3.70 Å | Mutation | Yes | [9] |
| PDB Sequence |
TVSLWETVQK
38 WREYRRQCQR48 SLTEDPPPAT58 DLFCNRTFDE68 YACWPDGEPG78 SFVNVSCPWY 88 LPWASSVPQG98 HVYRFCTAEG108 LWLQKDNSSL118 PWRDLSECEE128 SKRGERSSPE 138 EQLLFLYIIY148 TVGYALSFSA158 LVIASAILLG168 FRHLHCTRNY178 IHLNLFASFI 188 LRALSVFIKD198 AALKWMYSEA208 AQAHQWRGLL218 SYQDSLSCRL228 VFLFMQYCVA 238 ANYYWLLVEG248 VYLYTLLAFS258 VFSEQWIFRL268 YVSIGWGVPL278 LFVVPWGIVK 288 YLYEDEACWA298 RNSNMNYWLI308 IRLPILFAIG318 VNFLIFVRVI328 AIVVSKLKAN 338 LMCKTDIKCR348 LAKSTLTLIA358 LLATVEVIFA368 FVMDEHARGT378 LRFIKLFTEL 388 SFTSFQGLMV398 AILYCFANNE408 VQLEFRKSW
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .9DT or .9DT2 or .9DT3 or :39DT;style chemicals stick;color identity;select .A:141 or .A:144 or .A:148 or .A:197 or .A:198 or .A:201 or .A:384 or .A:388; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: WW35Kdg5EW | Ligand Info | |||||
| Structure Description | Crystal structure of thermostabilised full-length GLP-1R in complex with a truncated peptide agonist at 3.7 A resolution | PDB:5NX2 | ||||
| Method | X-ray diffraction | Resolution | 3.70 Å | Mutation | Yes | [9] |
| PDB Sequence |
TVSLWETVQK
38 WREYRRQCQR48 SLTEDPPPAT58 DLFCNRTFDE68 YACWPDGEPG78 SFVNVSCPWY 88 LPWASSVPQG98 HVYRFCTAEG108 LWLQKDNSSL118 PWRDLSECEE128 SKRGERSSPE 138 EQLLFLYIIY148 TVGYALSFSA158 LVIASAILLG168 FRHLHCTRNY178 IHLNLFASFI 188 LRALSVFIKD198 AALKWMYSEA208 AQAHQWRGLL218 SYQDSLSCRL228 VFLFMQYCVA 238 ANYYWLLVEG248 VYLYTLLAFS258 VFSEQWIFRL268 YVSIGWGVPL278 LFVVPWGIVK 288 YLYEDEACWA298 RNSNMNYWLI308 IRLPILFAIG318 VNFLIFVRVI328 AIVVSKLKAN 338 LMCKTDIKCR348 LAKSTLTLIA358 LLATVEVIFA368 FVMDEHARGT378 LRFIKLFTEL 388 SFTSFQGLMV398 AILYCFANNE408 VQLEFRKSW
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .9DW or .9DW2 or .9DW3 or :39DW;style chemicals stick;color identity;select .A:31 or .A:137 or .A:141 or .A:142 or .A:145 or .A:148 or .A:197 or .A:198 or .A:201 or .A:202 or .A:205; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| Ligand Name: 3,6,9,12,15,18-Hexaoxahexacosan-1-ol | Ligand Info | |||||
| Structure Description | Crystal structure of Semaglutide peptide backbone in complex with the GLP-1 receptor extracellular domain | PDB:4ZGM | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [10] |
| PDB Sequence |
TVSLWETVQK
38 WREYRRQCQR48 SLTEDPPPAT58 DLFCNRTFDE68 YACWPDGEPG78 SFVNVSCPWY 88 LPWASSVPQG98 HVYRFCTAEG108 LWLQKDNSSL118 PWRDLSECEE128 |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .32M or .32M2 or .32M3 or :332M;style chemicals stick;color identity;select .A:80 or .A:103 or .A:111 or .A:114 or .A:120 or .A:32 or .A:33 or .A:36 or .A:39 or .A:40 or .A:43; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: Decyl 4-O-Alpha-D-Glucopyranosyl-1-Thio-Beta-D-Glucopyranoside | Ligand Info | |||||
| Structure Description | Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain | PDB:3C5T | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [11] |
| PDB Sequence |
ATVSLWETVQ
37 KWREYRRQCQ47 RSLTEDPPPA57 TDLFCNRTFD67 EYACWPDGEP77 GSFVNVSCPW 87 YLPWASSVPQ97 GHVYRFCTAE107 GLWLQKDNSS117 LPWRDLSECE127 ESKR |
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .10M or .10M2 or .10M3 or :310M;style chemicals stick;color identity;select .A:80 or .A:82 or .A:97 or .A:99 or .A:101 or .A:125; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists. Mol Cell. 2020 Nov 5;80(3):485-500.e7. | ||||
| REF 2 | Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature. 2017 Jun 8;546(7657):312-315. | ||||
| REF 3 | Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor. Nat Commun. 2021 Jun 18;12(1):3763. | ||||
| REF 4 | Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes. Cell Rep. 2021 Jul 13;36(2):109374. | ||||
| REF 5 | Structural insights into probe-dependent positive allosterism of the GLP-1 receptor. Nat Chem Biol. 2020 Oct;16(10):1105-1110. | ||||
| REF 6 | Structural basis of peptidomimetic agonism revealed by small- molecule GLP-1R agonists Boc5 and WB4-24. Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2200155119. | ||||
| REF 7 | Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nat Commun. 2022 Feb 25;13(1):1057. | ||||
| REF 8 | Structural insights into the activation of GLP-1R by a small molecule agonist. Cell Res. 2020 Dec;30(12):1140-1142. | ||||
| REF 9 | Crystal structure of the GLP-1 receptor bound to a peptide agonist. Nature. 2017 Jun 8;546(7657):254-258. | ||||
| REF 10 | Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide. J Med Chem. 2015 Sep 24;58(18):7370-80. | ||||
| REF 11 | Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain. J Biol Chem. 2008 Apr 25;283(17):11340-7. | ||||
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