Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T39716 | Target Info | |||
| Target Name | Voltage-gated sodium channel alpha Nav1.5 (SCN5A) | ||||
| Synonyms | Voltage-gated sodium channel subunit alpha Nav1.5; Sodium channel protein type V subunit alpha; Sodium channel protein type 5 subunit alpha; Sodium channel protein cardiac muscle subunit alpha; HH1 | ||||
| Target Type | Successful Target | ||||
| Gene Name | SCN5A | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Quinidine | Ligand Info | |||||
| Structure Description | voltage-gated sodium channel Nav1.5 with quinidine | PDB:6LQA | ||||
| Method | Electron microscopy | Resolution | 3.30 Å | Mutation | No | [1] |
| PDB Sequence |
PIRRAAVKIL
128 VHSLFNMLIM138 CTILTNCVFM148 AQHDPPPWTK158 YVEYTFTAIY168 TFESLVKILA 178 RGFCLHAFTF188 LRDPWNWLDF198 SVIIMAYTTE208 FVDLGNVSAL218 RTFRVLRALK 228 TISVISGLKT238 IVGALIQSVK248 KLADVMVLTV258 FCLSVFALIG268 LQLFMGNLRH 278 KCVRNFTALN288 GTNGSVEADG298 LVWESLDLYL308 SDPENYLLKN318 GTSDVLLCGN 328 SSDAGTCPEG338 YRCLKAGENP348 DHGYTSFDSF358 AWAFLALFRL368 MTQDCWERLY 378 QQTLRSAGKI388 YMIFFMLVIF398 LGSFYLVNLI408 LAVVAMAYEE418 QNQATIAETE 428 ECCPLWMSIK707 QGVKLVVMDP717 FTDLTITMCI727 VLNTLFMALE737 HYNMTSEFEE 747 MLQVGNLVFT757 GIFTAEMTFK767 IIALDPYYYF777 QQGWNIFDSI787 IVILSLMELG 797 LSRMSNLSVL807 RSFRLLRVFK817 LAKSWPTLNT827 LIKIIGNSVG837 ALGNLTLVLA 847 IIVFIFAVVG857 MQLFGKNYSE867 LRDSDSGLLP877 RWHMMDFFHA887 FLIIFRILCG 897 EWIETMWDCM907 EVSGQSLCLL917 VFLLVMVIGN927 LVVLNLFLAL937 LLSSFSAGKV 1190 WWRLRKTCYH1200 IVEHSWFETF1210 IIFMILLSSG1220 ALAFEDIYLE1230 ERKTIKVLLE 1240 YADKMFTYVF1250 VLEMLLKWVA1260 YGFKKYFTNA1270 WCWLDFLIVD1280 VSLVSLVANT 1290 LGFAEMGPIK1300 SLRTLRALRP1310 LRALSRFEGM1320 RVVVNALVGA1330 IPSIMNVLLV 1340 CLIFWLIFSI1350 MGVNLFAGKF1360 GRCINQTEGD1370 LPLNYTIVNN1380 KSQCESLNLT 1390 GELYWTKVKV1400 NFDNVGAGYL1410 ALLQVATFKG1420 WMDIMYAAVD1430 SRGYEEQPQW 1440 EYNLYMYIYF1450 VIFIIFGSFF1460 TLNLFIGVII1470 DNFNQQKKKL1480 GGQDIFMTEE 1490 QKKYYNAMKK1500 LGSKKPQKPI1510 PRPLNKYQGF1520 IFDIVTKQAF1530 DVTIMFLICL 1540 NMVTMMVETD1550 DQSPEKINIL1560 AKINLLFVAI1570 FTGECIVKLA1580 ALRHYYFTNS 1590 WNIFDFVVVI1600 LSIVGTVLSD1610 IIQKYFFSPT1620 LFRVIRLARI1630 GRILRLIRGA 1640 KGIRTLLFAL1650 MMSLPALFNI1660 GLLLFLVMFI1670 YSIFGMANFA1680 YVKWEAGIDD 1690 MFNFQTFANS1700 MLCLFQITTS1710 AGWDGLLSPI1720 LNTGPPYCDP1730 TLPNSNGSRG 1740 DCGSPAVGIL1750 FFTTYIIISF1760 LIVVNMYIAI1770 ILENFSVATE1780 E |
|||||
|
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Na(v) 1.5 by the Antiarrhythmic Drug Quinidine*. Angew Chem Int Ed Engl. 2021 May 10;60(20):11474-11480. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.