Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T40730 Target Info
Target Name Bacterial Dihydroneopterinaldolase (Bact folB)
Synonyms folB of Escherichia coli; FOLB of Escherichia coli; DHNA of Escherichia coli; 7,8-Dihydroneopterin aldolase
Target Type Discontinued Target
Gene Name Bact folB
Biochemical Class Carbon-carbon lyase
UniProt ID
FOLB_ECOLI
Drug Binding Sites of Target  Top
Ligand Name: Neopterin Ligand Info
Structure Description Atomic resolution crystal structure of E.coli dihydroneopterin aldolase in complex with neopterin PDB:2O90
Method X-ray diffraction Resolution 1.07 Å Mutation No [1]
PDB Sequence
MDIVFIEQLS
10
VITTIGVYDW
20
EQTIEQKLVF
30
DIEMAWDNRK
40
AAKSDDVADC
50

LSYADIAETV
60
VSHVEGARFA
70
LVERVAEEVA
80
ELLLARFNSP
90
WVRIKLSKPG
100

AVARAANVGV
110
IIERG
Residue
Distance (Å)
GLY16
3.555
VAL17
3.044
TYR18
3.574
GLU21
2.577
ALA70
4.146
LEU71
3.407
Residue
Distance (Å)
VAL72
2.968
GLU73
2.743
LYS98
2.733
ALA101
3.529
VAL110
4.893
References  Top
REF 1 Crystallographic and molecular dynamics simulation analysis of Escherichia coli dihydroneopterin aldolase. Cell Biosci. 2014 Sep 2;4(1):52.

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