Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T45591 Target Info
Target Name Nucleophosmin (NPM1)
Synonyms Numatrin; Nucleolar protein NO38; Nucleolar phosphoprotein B23; NPM
Target Type Clinical trial Target
Gene Name NPM1
UniProt ID
NPM_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: L-serine-O-phosphate Ligand Info
Structure Description Crystal structure of 14-3-3 sigma in complex with NPM1 phosphopeptide and stabilizer Fusicoccin-A PDB:7OBH
Method X-ray diffraction Resolution 2.00 Å Mutation No [1]
PDB Sequence
QWRKL
Residue
Distance (Å)
TRP290
4.325
ARG291
1.928
Residue
Distance (Å)
LYS292
1.327
LEU294
1.323
Ligand Name: Fusicoccin Ligand Info
Structure Description Crystal structure of 14-3-3 sigma in complex with NPM1 phosphopeptide and stabilizer Fusicoccin-A PDB:7OBH
Method X-ray diffraction Resolution 2.00 Å Mutation No [1]
PDB Sequence
QWRKL
Residue
Distance (Å)
LEU294
2.368
Residue
Distance (Å)
References  Top
REF 1 IFN-alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol. 2023 Jun 15;30(6):573-590.e6.

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