Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T47094 | Target Info | |||
| Target Name | Substance-P receptor (TACR1) | ||||
| Synonyms | Tachykinin receptor 1; Tachykinin neurokinin 1 receptor; Tachykinin 1 receptor; TACR1; Substance P receptor; SPR; Neurokinin 1 receptor; NK-1R; NK-1 receptor | ||||
| Target Type | Successful Target | ||||
| Gene Name | TACR1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex | PDB:7P00 | ||||
| Method | Electron microscopy | Resolution | 2.71 Å | Mutation | Yes | [1] |
| PDB Sequence |
PNQFVQPAWQ
31 IVLWAAAYTV41 IVVTSVVGNV51 VVMWIILAHK61 RMRTVTNYFL71 VNLAFAEASM 81 AAFNTVVNFT91 YAVHNEWYYG101 LFYCKFHNFF111 PIAAVFASIY121 SMTAVAFDRY 131 MAIIHPLQPR141 LSATATKVVI151 CVIWVLALLL161 AFPQGYYSTT171 ETMPSRVVCM 181 IEWPEHPNKI191 YEKVYHICVT201 VLIYFLPLLV211 IGYAYTVVGI221 TLWAYHEQVS 241 AKRKVVKMMI251 VVVCTFAICW261 LPFHIFFLLP271 YINPDLYLKK281 FIQQVYLAIM 291 WLAMSSTMYN301 PIIYCCLNDR311 FRLGFKHA
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structures of neurokinin 1 receptor in complex with G(q) and G(s) proteins reveal substance P binding mode and unique activation features. Sci Adv. 2021 Dec 10;7(50):eabk2872. | ||||
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