Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T47768 | Target Info | |||
| Target Name | Opioid receptor mu (MOP) | ||||
| Synonyms | hMOP; Mu-type opioid receptor; Mu opioid receptor; Mu opiate receptor; MOR1A; MOR1; MOR-1; M-OR-1 | ||||
| Target Type | Successful Target | ||||
| Gene Name | OPRM1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Morphine | Ligand Info | |||||
| Structure Description | Morphine-bound mu-opioid receptor-Gi complex | PDB:8EF6 | ||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
SMITAITIMA
75 LYSIVCVVGL85 FGNFLVMYVI95 VRYTKMKTAT105 NIYIFNLALA115 DALATSTLPF 125 QSVNYLMGTW135 PFGTILCKIV145 ISIDYYNMFT155 SIFTLCTMSV165 DRYIAVCHPV 175 KALDFRTPRN185 AKIINVCNWI195 LSSAIGLPVM205 FMATTKYRQG215 SIDCTLTFSH 225 PTWYWENLLK235 ICVFIFAFIM245 PVLIITVCYG255 LMILRLKSVR265 MLSGSKEKDR 275 NLRRITRMVL285 VVVAVFIVCW295 TPIHIYVIIK305 ALVTIPETTF315 QTVSWHFCIA 325 LGYTNSCLNP335 VLYAFLDENF345 KRCFREF
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| Ligand Name: Oliceridine | Ligand Info | |||||
| Structure Description | Oliceridine-bound mu-opioid receptor-Gi complex | PDB:8EFB | ||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
TAITIMALYS
78 IVCVVGLFGN88 FLVMYVIVRY98 TKMKTATNIY108 IFNLALADAL118 ATSTLPFQSV 128 NYLMGTWPFG138 TILCKIVISI148 DYYNMFTSIW158 TLCTMSVDRY168 IAVCHPVKAL 178 DFRTPRNAKI188 INVCNWILSS198 AIGLPVMFMA208 TTKYRQGSID218 CTLTFSHPTW 228 YWENLLKICV238 FIFAFIMPVL248 IITVCYGLMI258 LRLKSVRMLS268 GSKEKDRNLR 278 RITRMVLVVV288 AVFIVCWTPI298 HIYVIIKALV308 TIPETTFQTV318 SWHFCIALGY 328 TNSCLNPVLY338 AFLDENFKRC348 FREF
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| Ligand Name: Fentanyl | Ligand Info | |||||
| Structure Description | Fentanyl-bound mu-opioid receptor-Gi complex | PDB:8EF5 | ||||
| Method | Electron microscopy | Resolution | 3.30 Å | Mutation | No | [1] |
| PDB Sequence |
SMITAITIMA
75 LYSIVCVVGL85 FGNFLVMYVI95 VRYTKMKTAT105 NIYIFNLALA115 DALATSTLPF 125 QSVNYLMGTW135 PFGTILCKIV145 ISIDYYNMFT155 SIFTLCTMSV165 DRYIAVCHPV 175 KALDFRTPRN185 AKIINVCNWI195 LSSAIGLPVM205 FMATTKYRQG215 SIDCTLTFSH 225 PTWYWENLLK235 ICVFIFAFIM245 PVLIITVCYG255 LMILRLKSVR265 MLSGSKEKDR 275 NLRRITRMVL285 VVVAVFIVCW295 TPIHIYVIIK305 ALVTIPETTF315 QTVSWHFCIA 325 LGYTNSCLNP335 VLYAFLDENF345 KRCFREF
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .7V7 or .7V72 or .7V73 or :37V7;style chemicals stick;color identity;select .R:126 or .R:129 or .R:135 or .R:145 or .R:146 or .R:149 or .R:150 or .R:153 or .R:219 or .R:238 or .R:295 or .R:298 or .R:299 or .R:302 or .R:324 or .R:327 or .R:328; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | PZM21-bound mu-opioid receptor-Gi complex | PDB:8EFO | ||||
| Method | Electron microscopy | Resolution | 2.80 Å | Mutation | No | [1] |
| PDB Sequence |
SMITAITIMA
75 LYSIVCVVGL85 FGNFLVMYVI95 VRYTKMKTAT105 NIYIFNLALA115 DALATSTLPF 125 QSVNYLMGTW135 PFGTILCKIV145 ISIDYYNMFT155 SIFTLCTMSV165 DRYIAVCHPV 175 KALDFRTPRN185 AKIINVCNWI195 LSSAIGLPVM205 FMATTKYRQG215 SIDCTLTFSH 225 PTWYWENLLK235 ICVFIFAFIM245 PVLIITVCYG255 LMILRLKSVR265 MLSGSKEKDR 275 NLRRITRMVL285 VVVAVFIVCW295 TPIHIYVIIK305 ALVTIPETTF315 QTVSWHFCIA 325 LGYTNSCLNP335 VLYAFLDENF345 KRCFREF
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CLR or .CLR2 or .CLR3 or :3CLR;style chemicals stick;color identity;select .R:101 or .R:107 or .R:110 or .R:111 or .R:114 or .R:118 or .R:151 or .R:152 or .R:154 or .R:158 or .R:165 or .R:168 or .R:169 or .R:173 or .R:176 or .R:187 or .R:191 or .R:194 or .R:196 or .R:199 or .R:200 or .R:203 or .R:207 or .R:228 or .R:229 or .R:230 or .R:232 or .R:233 or .R:234 or .R:236 or .R:237 or .R:241 or .R:245 or .R:248 or .R:249 or .R:252 or .R:253 or .R:256 or .R:292 or .R:293 or .R:296 or .R:297 or .R:300 or .R:301 or .R:304 or .R:306 or .R:307 or .R:310 or .R:311 or .R:315 or .R:316 or .R:319 or .R:323; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
MET101
3.608
ILE107
3.835
PHE110
3.650
ASN111
3.216
LEU114
3.722
LEU118
4.183
TYR151
3.514
ASN152
4.988
PHE154
4.772
PHE158
3.660
VAL165
3.664
TYR168
3.286
ILE169
3.677
HIS173
3.446
LYS176
3.371
LYS187
3.366
VAL191
3.757
TRP194
3.550
LEU196
3.742
ALA199
3.628
ILE200
3.692
PRO203
4.160
MET207
3.981
TRP228
3.674
TYR229
4.230
TRP230
3.966
ASN232
3.401
LEU233
3.758
LEU234
4.176
ILE236
3.658
CYS237
4.062
PHE241
3.631
MET245
3.931
LEU248
3.633
ILE249
3.654
VAL252
3.660
CYS253
4.823
LEU256
4.066
ILE292
4.769
VAL293
4.486
THR296
4.126
PRO297
3.661
ILE300
4.551
TYR301
3.490
ILE304
3.773
ALA306
3.406
LEU307
4.034
ILE310
4.358
PRO311
4.875
PHE315
4.205
GLN316
4.186
SER319
3.082
CYS323
4.413
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: D-Alanine | Ligand Info | |||||
| Structure Description | DAMGO-bound mu-opioid receptor-Gi complex | PDB:8EFQ | ||||
| Method | Electron microscopy | Resolution | 3.30 Å | Mutation | No | [1] |
| PDB Sequence |
MITAITIMAL
76 YSIVCVVGLF86 GNFLVMYVIV96 RYTKMKTATN106 IYIFNLALAD116 ALATSTLPFQ 126 SVNYLMGTWP136 FGTILCKIVI146 SIDYYNMFTS156 IFTLCTMSVD166 RYIAVCHPVK 176 ALDFRTPRNA186 KIINVCNWIL196 SSAIGLPVMF206 MATTKYRQGS216 IDCTLTFSHP 226 TWYWENLLKI236 CVFIFAFIMP246 VLIITVCYGL256 MILRLKSVRM266 LSGSKEKDRN 276 LRRITRMVLV286 VVAVFIVCWT296 PIHIYVIIKA306 LVTIPETTFQ316 TVSWHFCIAL 326 GYTNSCLNPV336 LYAFLDENFK346 RCF
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .DAL or .DAL2 or .DAL3 or :3DAL;style chemicals stick;color identity;select .R:126 or .R:298 or .R:302 or .R:320 or .R:324; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| Ligand Name: 1-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-[(2S)-1-(thiophen-3-yl)propan-2-yl]urea | Ligand Info | |||||
| Structure Description | PZM21-bound mu-opioid receptor-Gi complex | PDB:8EFO | ||||
| Method | Electron microscopy | Resolution | 2.80 Å | Mutation | No | [1] |
| PDB Sequence |
SMITAITIMA
75 LYSIVCVVGL85 FGNFLVMYVI95 VRYTKMKTAT105 NIYIFNLALA115 DALATSTLPF 125 QSVNYLMGTW135 PFGTILCKIV145 ISIDYYNMFT155 SIFTLCTMSV165 DRYIAVCHPV 175 KALDFRTPRN185 AKIINVCNWI195 LSSAIGLPVM205 FMATTKYRQG215 SIDCTLTFSH 225 PTWYWENLLK235 ICVFIFAFIM245 PVLIITVCYG255 LMILRLKSVR265 MLSGSKEKDR 275 NLRRITRMVL285 VVVAVFIVCW295 TPIHIYVIIK305 ALVTIPETTF315 QTVSWHFCIA 325 LGYTNSCLNP335 VLYAFLDENF345 KRCFREF
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .8QY or .8QY2 or .8QY3 or :38QY;style chemicals stick;color identity;select .R:122 or .R:126 or .R:129 or .R:135 or .R:145 or .R:146 or .R:149 or .R:150 or .R:153 or .R:219 or .R:235 or .R:238 or .R:295 or .R:298 or .R:299 or .R:302 or .R:320 or .R:324 or .R:328; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2M8P7Uaw4W | Ligand Info | |||||
| Structure Description | SR17018-bound mu-opioid receptor-Gi complex | PDB:8EFL | ||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
SMITAITIMA
75 LYSIVCVVGL85 FGNFLVMYVI95 VRYTKMKTAT105 NIYIFNLALA115 DALATSTLPF 125 QSVNYLMGTW135 PFGTILCKIV145 ISIDYYNMFT155 SIFTLCTMSV165 DRYIAVCHPV 175 KALDFRTPRN185 AKIINVCNWI195 LSSAIGLPVM205 FMATTKYRQG215 SIDCTLTFSH 225 PTWYWENLLK235 ICVFIFAFIM245 PVLIITVCYG255 LMILRLKSVR265 MLSGSKEKDR 275 NLRRITRMVL285 VVVAVFIVCW295 TPIHIYVIIK305 ALVTIPETTF315 QTVSWHFCIA 325 LGYTNSCLNP335 VLYAFLDENF345 KRCFREF
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .WH9 or .WH92 or .WH93 or :3WH9;style chemicals stick;color identity;select .R:122 or .R:125 or .R:126 or .R:129 or .R:135 or .R:145 or .R:146 or .R:149 or .R:150 or .R:153 or .R:219 or .R:238 or .R:295 or .R:298 or .R:299 or .R:302 or .R:320 or .R:328; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| Ligand Name: Ethanolamine | Ligand Info | |||||
| Structure Description | DAMGO-bound mu-opioid receptor-Gi complex | PDB:8EFQ | ||||
| Method | Electron microscopy | Resolution | 3.30 Å | Mutation | No | [1] |
| PDB Sequence |
MITAITIMAL
76 YSIVCVVGLF86 GNFLVMYVIV96 RYTKMKTATN106 IYIFNLALAD116 ALATSTLPFQ 126 SVNYLMGTWP136 FGTILCKIVI146 SIDYYNMFTS156 IFTLCTMSVD166 RYIAVCHPVK 176 ALDFRTPRNA186 KIINVCNWIL196 SSAIGLPVMF206 MATTKYRQGS216 IDCTLTFSHP 226 TWYWENLLKI236 CVFIFAFIMP246 VLIITVCYGL256 MILRLKSVRM266 LSGSKEKDRN 276 LRRITRMVLV286 VVAVFIVCWT296 PIHIYVIIKA306 LVTIPETTFQ316 TVSWHFCIAL 326 GYTNSCLNPV336 LYAFLDENFK346 RCF
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ETA or .ETA2 or .ETA3 or :3ETA;style chemicals stick;color identity;select .R:150 or .R:219 or .R:220 or .R:221; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-Methyl-L-phenylalanine | Ligand Info | |||||
| Structure Description | DAMGO-bound mu-opioid receptor-Gi complex | PDB:8EFQ | ||||
| Method | Electron microscopy | Resolution | 3.30 Å | Mutation | No | [1] |
| PDB Sequence |
MITAITIMAL
76 YSIVCVVGLF86 GNFLVMYVIV96 RYTKMKTATN106 IYIFNLALAD116 ALATSTLPFQ 126 SVNYLMGTWP136 FGTILCKIVI146 SIDYYNMFTS156 IFTLCTMSVD166 RYIAVCHPVK 176 ALDFRTPRNA186 KIINVCNWIL196 SSAIGLPVMF206 MATTKYRQGS216 IDCTLTFSHP 226 TWYWENLLKI236 CVFIFAFIMP246 VLIITVCYGL256 MILRLKSVRM266 LSGSKEKDRN 276 LRRITRMVLV286 VVAVFIVCWT296 PIHIYVIIKA306 LVTIPETTFQ316 TVSWHFCIAL 326 GYTNSCLNPV336 LYAFLDENFK346 RCF
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MEA or .MEA2 or .MEA3 or :3MEA;style chemicals stick;color identity;select .R:122 or .R:125 or .R:126 or .R:129 or .R:135 or .R:145 or .R:146 or .R:149 or .R:219 or .R:220; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Molecular recognition of morphine and fentanyl by the human u-opioid receptor. Cell. 2022 Nov 10;185(23):4361-4375.e19. | ||||
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