Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T49453 Target Info
Target Name Notch-4 receptor (NOTCH4)
Synonyms hNotch4; Notch 4; Neurogenic locus notch homolog protein 4; INT3
Target Type Clinical trial Target
Gene Name NOTCH4
Biochemical Class Notch protein
UniProt ID
NOTC4_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: L-serine-O-phosphate Ligand Info
Structure Description Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ136 PDB:7OR3
Method X-ray diffraction Resolution 1.80 Å Mutation No [1]
PDB Sequence
RRFAGMR
Residue
Distance (Å)
ARG1914
4.153
ARG1915
1.882
PHE1916
1.333
ALA1918
1.328
Residue
Distance (Å)
GLY1919
2.558
MET1920
2.323
ARG1921
3.660
Click to View More Binding Site Information of This Target and Ligand Pair
Ligand Name: N-[(5-carbamimidoyl-3-phenylthiophen-2-yl)methyl]-1H-indole-6-carboxamide Ligand Info
Structure Description Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ178 PDB:7OR7
Method X-ray diffraction Resolution 1.80 Å Mutation No [2]
PDB Sequence
RRFAGMR
Residue
Distance (Å)
ALA1918
4.639
Residue
Distance (Å)
Ligand Name: N-[(5-carbamimidoyl-3-phenylthiophen-2-yl)methyl]-2,3-dihydro-1-benzofuran-5-carboxamide Ligand Info
Structure Description Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ136 PDB:7OR3
Method X-ray diffraction Resolution 1.80 Å Mutation No [1]
PDB Sequence
RRFAGMR
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .0AW or .0AW2 or .0AW3 or :30AW;style chemicals stick;color identity;select .B:1918 or .B:1921; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
ALA1918
4.574
Residue
Distance (Å)
ARG1921
1.995
Ligand Name: N-[(5-carbamimidoyl-3-phenylthiophen-2-yl)methyl]-2,3-dihydro-1-benzofuran-7-carboxamide Ligand Info
Structure Description Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ162 PDB:7OR5
Method X-ray diffraction Resolution 1.80 Å Mutation No [3]
PDB Sequence
RRFAGM
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .09W or .09W2 or .09W3 or :309W;style chemicals stick;color identity;select .B:1918; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
ALA1918
4.920
Residue
Distance (Å)
References  Top
REF 1 A crystallography-based study of fragment extensions
REF 2 A crystallography-based study of fragment extensions
REF 3 A crystallography-based study of fragment extensions

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