Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T49627 | Target Info | |||
| Target Name | Mycobacterium Cytochrome p450 121 (MycB cyp121) | ||||
| Synonyms | Cytochrome P450 MT2; Cytochrome P450 121 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | MycB cyp121 | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 2-Amino-5-chlorobenzamide | Ligand Info | |||||
| Structure Description | Crystal structure of Mycobacterium tuberculosis CYP121 in complex with LIG9 | PDB:5EDT | ||||
| Method | X-ray diffraction | Resolution | 2.45 Å | Mutation | No | [1] |
| PDB Sequence |
TATVLLEVPF
11 SARGDRIPDA21 VAELRTREPI31 RKVRTITGAE41 AWLVSSYALC51 TQVLEDRRFS 61 MKETAAAGAP71 RLNALTVPPE81 VVNNMGNIAD91 AGLRKAVMKA101 ITPKAPGLEQ 111 FLRDTANSLL121 DNLITEGAPA131 DLRNDFADPL141 ATALHCKVLG151 IPQEDGPKLF 161 RSLSIAFMSS171 ADPIPAAKIN181 WDRDIEYMAG191 ILENPNITTG201 LMGELSRLRK 211 DPAYSHVSDE221 LFATIGVTFF231 GAGVISTGSF241 LTTALISLIQ251 RPQLRNLLHE 261 KPELIPAGVE271 ELLRINLSFA281 DGLPRLATAD291 IQVGDVLVRK301 GELVLVLLEG 311 ANFDPEHFPN321 PGSIELDRPN331 PTSHLAFGRG341 QHFCPGSALG351 RRHAQIGIEA 361 LLKKMPGVDL371 AVPIDQLVWR381 TRFQRRIPER391 LPVLW
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. J Med Chem. 2016 Apr 14;59(7):3272-302. | ||||
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