Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T51115 | Target Info | |||
Target Name | Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) | ||||
Synonyms | Voltage-gated calcium channel subunit alpha Cav1.2; Voltage-dependent L-type calcium channel subunit alpha-1C; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; CCHL1A1; CACNL1A1; CACN2; CACH2 | ||||
Target Type | Successful Target | ||||
Gene Name | CACNA1C | ||||
Biochemical Class | Voltage-gated ion channel | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: 1,3-Bis(bromomethyl)benzene | Ligand Info | |||||
Structure Description | CaV beta2a subunit: CaV1.2 AID-CEN complex | PDB:5V2Q | ||||
Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | Yes | [1] |
PDB Sequence |
ASPLEEDLCG
436 YLCWITQAE
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Click to View More Binding Site Information of This Target and Ligand Pair |
References | Top | ||||
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REF 1 | Stapled Voltage-Gated Calcium Channel (Ca(V)) Alpha-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of Ca(V) Function. ACS Chem Neurosci. 2017 Jun 21;8(6):1313-1326. |
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