Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T53024 | Target Info | |||
| Target Name | Somatostatin receptor type 2 (SSTR2) | ||||
| Synonyms | Sst(2); Somatostatin receptor 2; SS2R; SS2-R; SS-2-R; SRIF-1 | ||||
| Target Type | Successful Target | ||||
| Gene Name | SSTR2 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | Cryo-EM structure of the SST-14-bound SSTR2-miniGq-scFv16 complex | PDB:7Y27 | ||||
| Method | Electron microscopy | Resolution | 3.48 Å | Mutation | Yes | [1] |
| PDB Sequence |
LTSNAVLTFI
49 YFVVCIIGLC59 GNTLVIYVIL69 RYAKMKTITN79 IYILNLAIAD89 ELFMLGLPFL 99 AMQVALVHWP109 FGKAICRVVM119 TVDGINQFTS129 IFCLTVMSID139 RYLAVVHPIK 149 SAKWRRPRTA159 KMITMAVWGV169 SLLVILPIMI179 YAGLRSNQWG189 RSSCTINWPG 202 AWYTGFIIYT212 FILGFLVPLT222 IICLCYLFII232 IKVKSSKSEK252 KVTRMVSIVV 262 AVFIFCWLPF272 YIFNVSSVSM282 AISPTPALKG292 MFDFVVVLTY302 ANSCANPILY 312 AFLSDNFKKS322 FQNV
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| Ligand Name: (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 | Ligand Info | |||||
| Structure Description | Cryo-EM structure of the L-054,264-bound human SSTR2-Gi1 complex | PDB:7WIG | ||||
| Method | Electron microscopy | Resolution | 2.70 Å | Mutation | No | [2] |
| PDB Sequence |
LTSNAVLTFI
49 YFVVCIIGLC59 GNTLVIYVIL69 RTITNIYILN84 LAIADELFML94 GLPFLAMQVA 104 LVHWPFGKAI114 CRVVMTVDGI124 NQFTSIFCLT134 VMSIDRYLAV144 VHPIKSAKWR 154 RPRTAKMITM164 AVWGVSLLVI174 LPIMIYAGLR184 SNQWGRSSCT194 INWPGESGAW 204 YTGFIIYTFI214 LGFLVPLTII224 CLCYLFIIIK234 VKSSGIRVGS244 SKRKKSEKKV 254 TRMVSIVVAV264 FIFCWLPFYI274 FNVSSVSMAI284 SPTPALKGMF294 DFVVVLTYAN 304 SCANPILYAF314 LSDNFKKSFQ324 NVL
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PHE92
4.804
LEU99
4.765
MET119
4.027
ASP122
2.500
GLN126
2.844
PHE127
4.450
ILE177
4.988
THR194
4.410
ILE195
4.602
TYR205
4.056
PHE208
4.512
THR212
4.286
PHE272
2.896
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Molecular basis for the selective G protein signaling of somatostatin receptors. Nat Chem Biol. 2023 Feb;19(2):133-140. | ||||
| REF 2 | Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes. Cell Res. 2022 Aug;32(8):785-788. | ||||
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