Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T53103 | Target Info | |||
| Target Name | Alpha-N-acetylglucosaminidase (NAGLU) | ||||
| Synonyms | UFHSD1; NAGLU; NAG; N-acetyl-alpha-glucosaminidase; Alpha-N-acetylglucosaminidase82 kDa form; Alpha-N-acetylglucosaminidase77 kDa form | ||||
| Target Type | Successful Target | ||||
| Gene Name | NAGLU | ||||
| Biochemical Class | Glycosylase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 1-Phosphono-L-histidine | Ligand Info | |||||
| Structure Description | Crystal structure of the human N-acetyl-alpha-glucosaminidase | PDB:4XWH | ||||
| Method | X-ray diffraction | Resolution | 2.32 Å | Mutation | No | [1] |
| PDB Sequence |
DEAREAAAVR
33 ALVARLLGPG43 PAADFSVSVE53 RALAAKPGLD63 TYSLGGGGAA73 RVRVRGSTGV 83 AAAAGLHRYL93 RDFCGCHVAW103 SGSQLRLPRP113 LPAVPGELTE123 ATPNRYRYYQ 133 NVCTQSYSFV143 WWDWARWERE153 IDWMALNGIN163 LALAWSGQEA173 IWQRVYLALG 183 LTQAEINEFF193 TGPAFLAWGR203 MGNLHTWDGP213 LPPSWHIKQL223 YLQHRVLDQM 233 RSFGMTPVLP243 AFAGHVPEAV253 TRVFPQVNVT263 KMGSWGHFNC273 SYSCSFLLAP 283 EDPIFPIIGS293 LFLRELIKEF303 GTDIYGADTF314 NEMQPPSSEP324 SYLAAATTAV 334 YEAMTAVDTE344 AVWLLQGWLF354 QHQPQFWGPA364 QIRAVLGAVP374 RGRLLVLDLF 384 AESQPVYTRT394 ASFQGQPFIW404 CMLHNFGGNH414 GLFGALEAVN424 GGPEAARLFP 434 NSTMVGTGMA444 PEGISQNEVV454 YSLMAELGWR464 KDPVPDLAAW474 VTSFAARRYG 484 VSHPDAGAAW494 RLLLRSVYNC504 SGEACRGHNR514 SPLVRRPSLQ524 MNTSIWYNRS 534 DVFEAWRLLL544 TSAPSLATSP554 AFRYDLLDLT564 RQAVQELVSL574 YYEEARSAYL 584 SKELASLLRA594 GGVLAYELLP604 ALDEVLASDS614 RFLLGSWLEQ624 ARAAAVSEAE 634 ADFYEQNSRY644 QLTLWGPEGN654 ILDYANKQLA664 GLVANYYTPR674 WRLFLEALVD 684 SVAQGIPFQQ694 HQFDKNVFQL704 EQAFVLSKQR714 YPSQPRGDTV724 DLAKKIFLKY 734 YPRWVAGSW
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| Ligand Name: Xylitol | Ligand Info | |||||
| Structure Description | Crystal structure of the human N-acetyl-alpha-glucosaminidase | PDB:4XWH | ||||
| Method | X-ray diffraction | Resolution | 2.32 Å | Mutation | No | [1] |
| PDB Sequence |
DEAREAAAVR
33 ALVARLLGPG43 PAADFSVSVE53 RALAAKPGLD63 TYSLGGGGAA73 RVRVRGSTGV 83 AAAAGLHRYL93 RDFCGCHVAW103 SGSQLRLPRP113 LPAVPGELTE123 ATPNRYRYYQ 133 NVCTQSYSFV143 WWDWARWERE153 IDWMALNGIN163 LALAWSGQEA173 IWQRVYLALG 183 LTQAEINEFF193 TGPAFLAWGR203 MGNLHTWDGP213 LPPSWHIKQL223 YLQHRVLDQM 233 RSFGMTPVLP243 AFAGHVPEAV253 TRVFPQVNVT263 KMGSWGHFNC273 SYSCSFLLAP 283 EDPIFPIIGS293 LFLRELIKEF303 GTDIYGADTF314 NEMQPPSSEP324 SYLAAATTAV 334 YEAMTAVDTE344 AVWLLQGWLF354 QHQPQFWGPA364 QIRAVLGAVP374 RGRLLVLDLF 384 AESQPVYTRT394 ASFQGQPFIW404 CMLHNFGGNH414 GLFGALEAVN424 GGPEAARLFP 434 NSTMVGTGMA444 PEGISQNEVV454 YSLMAELGWR464 KDPVPDLAAW474 VTSFAARRYG 484 VSHPDAGAAW494 RLLLRSVYNC504 SGEACRGHNR514 SPLVRRPSLQ524 MNTSIWYNRS 534 DVFEAWRLLL544 TSAPSLATSP554 AFRYDLLDLT564 RQAVQELVSL574 YYEEARSAYL 584 SKELASLLRA594 GGVLAYELLP604 ALDEVLASDS614 RFLLGSWLEQ624 ARAAAVSEAE 634 ADFYEQNSRY644 QLTLWGPEGN654 ILDYANKQLA664 GLVANYYTPR674 WRLFLEALVD 684 SVAQGIPFQQ694 HQFDKNVFQL704 EQAFVLSKQR714 YPSQPRGDTV724 DLAKKIFLKY 734 YPRWVAGSW
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TYR65
3.656
ALA86
4.579
ALA87
2.839
GLY88
4.720
HIS90
3.172
ARG91
3.682
ARG94
2.909
CYS136
3.955
TYR140
2.511
LEU159
2.653
ASN160
2.364
GLY161
4.587
TRP201
3.035
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural characterization of the Alpha-N-acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B. J Struct Biol. 2019 Mar 1;205(3):65-71. | ||||
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