Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T55094 | Target Info | |||
| Target Name | Acid-sensing ion channel 1 (ASIC1) | ||||
| Synonyms | Brain sodium channel 2; BNaC2; Amiloride-sensitive cation channel 2, neuronal; ASIC1; ACCN2 | ||||
| Target Type | Successful Target | ||||
| Gene Name | ASIC1 | ||||
| Biochemical Class | Amiloride-sensitive sodium channel | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose | Ligand Info | |||||
| Structure Description | hASIC1a co-crystallized with Nafamostat | PDB:6L6N | ||||
| Method | X-ray diffraction | Resolution | 2.86 Å | Mutation | No | [1] |
| PDB Sequence |
LWALCFLGSL
54 AVLLCVCTER64 VQYYFHYHHV74 TKLDEVAASQ84 LTFPAVTLCN94 LNEFRFSQVS 104 KNDLYHAGEL114 LALLNNRYEI124 PDTQMADEKQ134 LEILQDKANF144 RSFKPKPFNM 154 REFYDRAGHD164 IRDMLLSCHF174 RGEVCSAEDF184 KVVFTRYGKC194 YTFNSGRDGR 204 PRLKTMKGGT214 GNGLEIMLDI224 QQDEYLPVWG234 ETDETSFEAG244 IKVQIHSQDE 254 PPFIDQLGFG264 VAPGFQTFVA274 CQEQRLIYLP284 PPWGTCKAVT294 MDSDLDFFDS 304 YSITACRIDC314 ETRYLVENCN324 CRMVHMPGDA334 PYCTPEQYKE344 CADPALDFLV 354 EKDQEYCVCE364 MPCNLTRYGK374 ELSMVKIPSK384 ASAKYLAKKF394 NKSEQYIGEN 404 ILVLDIFFEV414 LNYETIEQKK424 AYEIAGLLGD434 IGGQMGLFIG444 ASILT |
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| Ligand Name: Cholesterol hemisuccinate | Ligand Info | |||||
| Structure Description | Cryo-EM strucutre of human acid-sensing ion channel 1a at pH 8.0 | PDB:7CFS | ||||
| Method | Electron microscopy | Resolution | 3.56 Å | Mutation | No | [2] |
| PDB Sequence |
SLKRALWALC
49 FLGSLAVLLC59 VCTERVQYYF69 HYHHVTKLDE79 VAASQLTFPA89 VTLCNLNEFR 99 FSQVSKNDLY109 HAGELLALLN119 NRYEIPDTQM129 ADEKQLEILQ139 DKANFRSFKP 149 KPFNMREFYD159 RAGHDIRDML169 LSCHFRGEVC179 SAEDFKVVFT189 RYGKCYTFNS 199 GRDGRPRLKT209 MKGGTGNGLE219 IMLDIQQDEY229 LPVWGETDET239 SFEAGIKVQI 249 HSQDEPPFID259 QLGFGVAPGF269 QTFVACQEQR279 LIYLPPPWGT289 CKAVTMDSDL 299 DFFDSYSITA309 CRIDCETRYL319 VENCNCRMVH329 MPGDAPYCTP339 EQYKECADPA 349 LDFLVEKDQE359 YCVCEMPCNL369 TRYGKELSMV379 KIPSKASAKY389 LAKKFNKSEQ 399 YIGENILVLD409 IFFEVLNYET419 IEQKKAYEIA429 GLLGDIGGQM439 GLFIGASILT 449 VLELFDYAYE459 VIKHKL
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | hASIC1a co-crystallized with Mamb-1 | ||||
| REF 2 | Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1. Elife. 2020 Sep 11;9:e57096. | ||||
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