Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T55815 | Target Info | |||
| Target Name | Neuronal acetylcholine receptor alpha-2 (CHRNA2) | ||||
| Synonyms | CHRNA2 | ||||
| Target Type | Successful Target | ||||
| Gene Name | CHRNA2 | ||||
| Biochemical Class | Neurotransmitter receptor | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Epibatidine | Ligand Info | |||||
| Structure Description | Crystal structure of the extracellular domain of alpha2 nicotinic acetylcholine receptor in pentameric assembly | PDB:5FJV | ||||
| Method | X-ray diffraction | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
DRLFKHLFRG
43 YNRWARPVPN53 TSDVVIVRFG63 LSIAQLIDVD73 EKNQMMTTNV83 WLKQEWSDYK 93 LRWNPTDFGN103 ITSLRVPSEM113 IWIPDIVLYN123 NADGEFAVTH133 MTKAHLFSTG 143 TVHWVPPAIY153 KSSCSIDVTF163 FPFDQQNCKM173 KFGSWTYDKA183 KIDLEQMEQT 193 VDLKDYWESG203 EWAIVNATGT213 YNSKKYDCCA223 EIYPDVTYAF233 VIRRLPH |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound Alpha2 homopentamer. Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9635-40. | ||||
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