Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T55948 | Target Info | |||
| Target Name | Organic cation transporter 3 (OCT3) | ||||
| Synonyms | Solute carrier family 22 member 3; Extraneuronal monoamine transporter; EMTH | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SLC22A3 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: (11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE | Ligand Info | |||||
| Structure Description | Structure of human OCT3 in complex with inhibitor Corticosterone | PDB:7ZH6 | ||||
| Method | Electron microscopy | Resolution | 3.67 Å | Mutation | No | [1] |
| PDB Sequence |
SFDEALQRVG
12 EFGRFQRRVF22 LLLCLTGVTF32 AFLFVGVVFL42 GTQPDHYWCR52 GPSAAALAER 62 CGWSPEEEWN72 RTAPASRGRC90 QRYLLSAPLV125 PCRGGWRYAQ135 AHSTIVSEFD 145 LVCVNAWMLD155 LTQAILNLGF165 LTGAFTLGYA175 ADRYGRIVIY185 LLSCLGVGVT 195 GVVVAFAPNF205 PVFVIFRFLQ215 GVFGKGTWMT225 CYVIVTEIVG235 SKQRRIVGIV 245 IQMFFTLGII255 ILPGIAYFIP265 NWQGIQLAIT275 LPSFLFLLYY285 WVVPESPRWL 295 ITRKKGDKAL305 QILRRIAKCN315 VSNPSFLDLV342 RTPQMRKCTL352 ILMFAWFTSA 362 VVYQGLVMRL372 GNLYIDFFIS386 GVVELPGALL396 ILLTIERLGR406 RLPFAASNIV 416 AGVACLVTAF426 LPEGIAWLRT436 TVATLGRLGI446 TMAFEIVYLV456 NSELYPTTLR 466 NFGVSLCSGL476 CDFGGIIAPF486 LLFRLAAVWL496 ELPLIIFGIL506 ASICGGLVML 516 LPETKGIALP526 ETVDDVEK
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| Ligand Name: 1-Ethyl-2-[(1-ethylquinolin-2-yl)methyl]quinoline | Ligand Info | |||||
| Structure Description | Structure of human OCT3 in complex with inhibitor decynium-22 | PDB:7ZHA | ||||
| Method | Electron microscopy | Resolution | 3.55 Å | Mutation | No | [1] |
| PDB Sequence |
SFDEALQRVG
12 EFGRFQRRVF22 LLLCLTGVTF32 AFLFVGVVFL42 GTQPDHYWCR52 GPSAAALAER 62 CGWSPEEEWN72 RTAPASRGRC90 QRYLLEAPLV125 PCRGGWRYAQ135 AHSTIVSEFD 145 LVCVNAWMLD155 LTQAILNLGF165 LTGAFTLGYA175 ADRYGRIVIY185 LLSCLGVGVT 195 GVVVAFAPNF205 PVFVIFRFLQ215 GVFGKGTWMT225 CYVIVTEIVG235 SKQRRIVGIV 245 IQMFFTLGII255 ILPGIAYFIP265 NWQGIQLAIT275 LPSFLFLLYY285 WVVPESPRWL 295 ITRKKGDKAL305 QILRRIAKCN315 GDEEVSNPSF338 LDLVRTPQMR348 KCTLILMFAW 358 FTSAVVYQGL368 VMRLGIIGGN378 LYIDFFISGV388 VELPGALLIL398 LTIERLGRRL 408 PFAASNIVAG418 VACLVTAFLP428 EGIAWLRTTV438 ATLGRLGITM448 AFEIVYLVNS 458 ELYPTTLRNF468 GVSLCSGLCD478 FGGIIAPFLL488 FRLAAVWLEL498 PLIIFGILAS 508 ICGGLVMLLP518 ETKGIALPET528 VDDVEKL
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis of organic cation transporter-3 inhibition. Nat Commun. 2022 Nov 7;13(1):6714. | ||||
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