Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T59654 | Target Info | |||
| Target Name | Polo-like kinase 2 (PLK2) | ||||
| Synonyms | hSNK; hPlk2; Serum-inducible kinase; Serine/threonine-protein kinase SNK; Serine/threonine-protein kinase PLK2; SNK; PLK-2 | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | PLK2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: BI 2536 | Ligand Info | |||||
| Structure Description | Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain | PDB:4I5M | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [1] |
| PDB Sequence |
RIIVDPTTGK
51 RYSRGKTLGK61 GGFAKCYEMT71 DLTNNKVYAA81 KIIPHSRVSK91 PHQREKIDKE 101 IELHRILHHK111 HVVQFYHYFE121 DKENIYILLE131 YCSRRSMAHI141 LKARKVLTEP 151 EVRYYLRQIV161 SGLKYLHEQE171 ILHRDLKLGN181 FFINESMELK191 VGDFGLAARL 201 ETPNYLSPEV222 LNKQGHGAES232 DIWALGCVMY242 TMLLGRPPFE252 TTNLKETYRS 262 IREARYTMPS272 SLLAPAKHLI282 ASMLSKNPED292 RPSLDDIIRH302 DFFTQGFTPD 312 RLSSSCCHTV322 PDF
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| Ligand Name: (7r)-8-Cyclopentyl-7-Ethyl-5-Methyl-2-(1h-Pyrrol-2-Yl)-7,8-Dihydropteridin-6(5h)-One | Ligand Info | |||||
| Structure Description | Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain | PDB:4I5P | ||||
| Method | X-ray diffraction | Resolution | 1.74 Å | Mutation | Yes | [1] |
| PDB Sequence |
RIIVDPTTGK
80 RYSRGKTLGK90 GGFAKCYEMT100 DLTNNKVYAA110 KIIPHSRVSK120 PHQREKIDKE 130 IELHRILHHK140 HVVQFYHYFE150 DKENIYILLE160 YCSRRSMAHI170 LKARKVLTEP 180 EVRYYLRQIV190 SGLKYLHEQE200 ILHRDLKLGN210 FFINESMELK220 VGDFGLAARL 230 EPLEHRRRTI240 CGTPNYLSPE250 VLNKQGHGAE260 SDIWALGCVM270 YTMLLGRPPF 280 ETTNLKETYR290 SIREARYTMP300 SSLLAPAKHL310 IASMLSKNPE320 DRPSLDDIIR 330 HDFFTQGFTP340 DRLSSSCCHT350 VPDF
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| Ligand Name: (7r)-8-Cyclopentyl-7-Ethyl-5-Methyl-7,8-Dihydropteridin-6(5h)-One | Ligand Info | |||||
| Structure Description | Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain | PDB:4I6B | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [1] |
| PDB Sequence |
RIIVDPTTGK
80 RYSRGKTLGK90 GGFAKCYEMT100 DLTNNKVYAA110 KIIPHSRVSK120 PHQREKIDKE 130 IELHRILHHK140 HVVQFYHYFE150 DKENIYILLE160 YCSRRSMAHI170 LKARKVLTEP 180 EVRYYLRQIV190 SGLKYLHEQE200 ILHRDLKLGN210 FFINESMELK220 VGDFGLAARL 230 EPLEHRRRTI240 CGTPNYLSPE250 VLNKQGHGAE260 SDIWALGCVM270 YTMLLGRPPF 280 ETTNLKETYR290 SIREARYTMP300 SSLLAPAKHL310 IASMLSKNPE320 DRPSLDDIIR 330 HDFFTQGFTP340 DRLSSSCCHT350 VPDFH
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .11G or .11G2 or .11G3 or :311G;style chemicals stick;color identity;select .A:88 or .A:89 or .A:90 or .A:91 or .A:96 or .A:109 or .A:110 or .A:111 or .A:143 or .A:159 or .A:160 or .A:161 or .A:162 or .A:212 or .A:223; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (7r)-8-Cyclopentyl-7-Ethyl-5-Methyl-2-[2-(1,3-Thiazol-4-Yl)-1h-Imidazol-1-Yl]-7,8-Dihydropteridin-6(5h)-One | Ligand Info | |||||
| Structure Description | Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce alpha-Synuclein Phosphorylation in Rat Brain | PDB:4I6H | ||||
| Method | X-ray diffraction | Resolution | 1.91 Å | Mutation | Yes | [1] |
| PDB Sequence |
RIIVDPTTGK
80 RYSRGKTLGK90 GGFAKCYEMT100 DLTNNKVYAA110 KIIPHSRVSK120 PHQREKIDKE 130 IELHRILHHK140 HVVQFYHYFE150 DKENIYILLE160 YCSRRSMAHI170 LKARKVLTEP 180 EVRYYLRQIV190 SGLKYLHEQE200 ILHRDLKLGN210 FFINESMELK220 VGDFGLAARL 230 EPLEHRRRTI240 CGTPNYLSPE250 VLNKQGHGAE260 SDIWALGCVM270 YTMLLGRPPF 280 ETTNLKETYR290 SIREARYTMP300 SSLLAPAKHL310 IASMLSKNPE320 DRPSLDDIIR 330 HDFFTQGFTP340 DRLSSSCCHT350 VPDFH
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .1C8 or .1C82 or .1C83 or :31C8;style chemicals stick;color identity;select .A:88 or .A:89 or .A:90 or .A:91 or .A:96 or .A:109 or .A:110 or .A:111 or .A:143 or .A:159 or .A:160 or .A:161 or .A:162 or .A:163 or .A:165 or .A:166 or .A:169 or .A:212 or .A:223; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (7r)-8-Cyclopentyl-7-Ethyl-5-Methyl-2-(2-Phenyl-1h-Imidazol-1-Yl)-7,8-Dihydropteridin-6(5h)-One | Ligand Info | |||||
| Structure Description | Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain | PDB:4I6F | ||||
| Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | Yes | [1] |
| PDB Sequence |
RIIVDPTTGK
80 RYSRGKTLGK90 GGFAKCYEMT100 DLTNNKVYAA110 KIIPHSRVSK120 PHQREKIDKE 130 IELHRILHHK140 HVVQFYHYFE150 DKENIYILLE160 YCSRRSMAHI170 LKARKVLTEP 180 EVRYYLRQIV190 SGLKYLHEQE200 ILHRDLKLGN210 FFINESMELK220 VGDFGLAARL 230 EPLEHRRRTI240 CGTPNYLSPE250 VLNKQGHGAE260 SDIWALGCVM270 YTMLLGRPPF 280 ETTNLKETYR290 SIREARYTMP300 SSLLAPAKHL310 IASMLSKNPE320 DRPSLDDIIR 330 HDFFTQGFTP340 DRLSSSCCHT350 VPDFH
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .1C7 or .1C72 or .1C73 or :31C7;style chemicals stick;color identity;select .A:88 or .A:89 or .A:90 or .A:91 or .A:96 or .A:109 or .A:110 or .A:111 or .A:143 or .A:159 or .A:160 or .A:161 or .A:162 or .A:163 or .A:165 or .A:166 or .A:169 or .A:212 or .A:223; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce Alpha-synuclein phosphorylation in rat brain. ChemMedChem. 2013 Aug;8(8):1295-313. | ||||
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