Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T60636 | Target Info | |||
| Target Name | Alpha-ketoglutarate dehydrogenase (OGDH) | ||||
| Synonyms | OGDC-E1; 2-oxoglutarate dehydrogenase, mitochondrial; 2-oxoglutarate dehydrogenase complex component E1 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | OGDH | ||||
| Biochemical Class | Aldehyde/oxo donor oxidoreductase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Thiamin diphosphate | Ligand Info | |||||
| Structure Description | Cryo-electron microscopic structure of the 2-oxoglutarate dehydrogenase (E1) component of the human alpha-ketoglutarate (2-oxoglutarate) dehydrogenase complex | PDB:7WGR | ||||
| Method | Electron microscopy | Resolution | 2.92 Å | Mutation | No | [1] |
| PDB Sequence |
AVQSLIRAYQ
138 IRGHHVAQLD148 PLGILDADLD158 SSVPADIISS168 TDKLGFYGLD178 ESDLDKVFHL 188 PTTTFIGGQE198 SALPLREIIR208 RLEMAYCQHI218 GVEFMFINDL228 EQCQWIRQKF 238 ETPGIMQFTN248 EEKRTLLARL258 VRSTRFEEFL268 QRKWSSEKRF278 GLEGCEVLIP 288 ALKTIIDKSS298 ENGVDYVIMG308 MPHRGRLNVL318 ANVIRKELEQ328 IFCQFDSKLE 338 AADEGSGDNI366 TLSLVANPSH376 LEAADPVVMG386 KTKAEQFYCG396 DTEGKKVMSI 406 LLHGDAAFAG416 QGIVYETFHL426 SDLPSYTTHG436 TVHVVVNNQI446 GFTTDPRMAR 456 SSPYPTDVAR466 VVNAPIFHVN476 SDDPEAVMYV486 CKVAAEWRST496 FHKDVVVDLV 506 CYRRNGHNEM516 DEPMFTQPLM526 YKQIRKQKPV536 LQKYAELLVS546 QGVVNQPEYE 556 EEISKYDKIC566 EEAFARSKMS603 CPSTGLTEDI613 LTHIGNVASS623 VPVENFTIHG 633 GLSRILKTRG643 EMVKNRTVDW653 ALAEYMAFGS663 LLKEGIHIRL673 SGQDVERGTF 683 SHRHHVLHDQ693 NVDKRTCIPM703 NHLWPNQAPY713 TVCNSSLSEY723 GVLGFELGFA 733 MASPNALVLW743 EAQFGDFHNT753 AQCIIDQFIC763 PGQAKWVRQN773 GIVLLLPHGM 783 EGMGPEHSSA793 RPERFLQMCN803 DDPDVLPDLK813 EANFDINQLY823 DCNWVVVNCS 833 TPGNFFHVLR843 RQILLPFRKP853 LIIFTPKSLL863 RHPEARSSFD873 EMLPGTHFQR 883 VIPEDGPAAQ893 NPENVKRLLF903 CTGKVYYDLT913 RERKARDMVG923 QVAITRIEQL 933 SPFPFDLLLK943 EVQKYPNAEL953 AWCQEEHKNQ963 GYYDYVKPRL973 RTTISRAKPV 983 WYAGRDPAAA993 PATGNKKTHL1003 TELQRLLDTA1013 FDLDVFKNFS1023 |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis for the activity and regulation of human alpha-ketoglutarate dehydrogenase revealed by Cryo-EM. doi:10.1016/j.bbrc.2022.02.093. | ||||
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