Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T62184 | Target Info | |||
| Target Name | GABA transporter GAT-1 (SLC6A1) | ||||
| Synonyms | Solute carrier family 6 member 1; Sodium- and chloride-dependent GABA transporter 1; GAT1; GAT-1; GABT1; GABATR; GABA transporter 1 | ||||
| Target Type | Successful Target | ||||
| Gene Name | SLC6A1 | ||||
| Biochemical Class | Neurotransmitter:sodium symporter | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Tiagabine | Ligand Info | |||||
| Structure Description | Human wildtype GABA reuptake transporter 1 in complex with tiagabine, inward-open conformation | PDB:7SK2 | ||||
| Method | Electron microscopy | Resolution | 3.82 Å | Mutation | No | [1] |
| PDB Sequence |
WKGRFDFLMS
56 CVGYAIGLGN66 VWRFPYLCGK76 NGGGAFLIPY86 FLTLIFAGVP96 LFLLECSLGQ 106 YTSIGGLGVW116 KLAPMFKGVG126 LAAAVLSFWL136 NIYYIVIISW146 AIYYLYNSFT 156 TTLPWKQCDN166 PWNTDRCFSN176 YSMVNTTNMT186 SAVVEFWERN196 MHQMTDGLDK 206 PGQIRWPLAI216 TLAIAWILVY226 FCIWKGVGWT236 GKVVYFSATY246 PYIMLIILFF 256 RGVTLPGAKE266 GILFYITPNF276 RKLSDSEVWL286 DAATQIFFSY296 GLGLGSLIAL 306 GSYNSFHNNV316 YRDSIIVCCI326 NSCTSMFAGF336 VIFSIVGFMA346 HVTKRSIADV 356 AASGPGLAFL366 AYPEAVTQLP376 ISPLWAILFF386 SMLLMLGIDS396 QFCTVEGFIT 406 ALVDEYPRLL416 RNRRELFIAA426 VCIISYLIGL436 SNITQGGIYV446 FKLFDYYSAS 456 GMSLLFLVFF466 ECVSISWFYG476 VNRFYDNIQE486 MVGSRPCIWW496 KLCWSFFTPI 506 IVAGVFIFSA516 VQMTPLTMGN526 YVFPKWGQGV536 GWLMALSSMV546 LIPGYMAYMF 556 LTLKGSLKQR566 IQVMVQPSED576 IV
|
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GLY59
4.429
TYR60
3.539
ALA61
4.764
ILE62
4.805
GLY63
3.135
LEU64
2.698
GLY65
2.435
ASN66
4.593
PHE98
3.942
LEU136
4.549
TYR140
3.902
PHE294
3.920
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis of GABA reuptake inhibition. Nature. 2022 Jun;606(7915):820-826. | ||||
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