Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T63934 Target Info
Target Name Interferon-alpha 2 (IFNA2)
Synonyms LeIF A; Interferon alphaA; Interferon alpha2; Interferon alpha-A; Interferon alpha-2; IFNalpha2; IFNA2C; IFNA2B; IFNA2A; IFN-alpha-2
Target Type Successful Target
Gene Name IFNA2
Biochemical Class Cytokine: interferon
UniProt ID
IFNA2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: N-Acetyl-2-deoxy-2-amino-galactose Ligand Info
Structure Description A single GalNAc residue on Threonine-106 modifies the dynamics and the structure of Interferon alpha-2a around the glycosylation site PDB:2LMS
Method Solution NMR Resolution N.A. Mutation No [1]
PDB Sequence
CDLPQTHSLG
10
SRRTLMLLAQ
20
MRKISLFSCL
30
KDRHDFGFPQ
40
EEFGNQFQKA
50

ETIPVLHEMI
60
QQIFNLFSTK
70
DSSAAWDETL
80
LDKFYTELYQ
90
QLNDLEACVI
100

QGVGVTETPL
110
MKEDSILAVR
120
KYFQRITLYL
130
KEKKYSPCAW
140
EVVRAEIMRS
150

FSLSTNLQES
160
LRSKE
Residue
Distance (Å)
GLY102
4.904
GLY104
4.646
VAL105
2.093
THR106
1.540
Residue
Distance (Å)
GLU107
2.654
THR108
3.001
PRO109
4.172
References  Top
REF 1 A single N-acetylgalactosamine residue at threonine 106 modifies the dynamics and structure of interferon Alpha2a around the glycosylation site. J Biol Chem. 2013 Jan 4;288(1):247-54.

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