Binding Site Information of Target

Content Navigation (  All   None )                                      
Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T63966 Target Info
Target Name Vascular endothelial growth factor receptor 1 (FLT-1)
Synonyms Vascular permeability factor receptor; VEGFR1; VEGFR-1; VEGF-1 receptor; Tyrosine-protein kinase receptor FLT; Tyrosine-protein kinase FRT; Fms-like tyrosine kinase 1; FRT; FLT
Target Type Successful Target
Gene Name FLT1
Biochemical Class Kinase
UniProt ID
VGFR1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: AG-E-85378 Ligand Info
Structure Description Crystal structure of VEGFR1 in complex with N-(4-Chlorophenyl)-2-((pyridin-4-ylmethyl)amino)benzamide PDB:3HNG
Method X-ray diffraction Resolution 2.70 Å Mutation No [1]
PDB Sequence
EVPLDEQCER
812
PYDASKWEFA
823
RERLKLGKSL
833
GRGAFGKVVQ
843
ASAFGIKKSP
853

TCRTVAVKML
863
KEGATASEYK
873
ALMTELKILT
883
HIGHHLNVVN
893
LLGACTKQGG
903

PLMVIVEYCK
913
YGNLSNYLKS
923
KRKEPITMED
998
LISYSFQVAR
1008
GMEFLSSRKC
1018

IHRDLAARNI
1028
LLSENNVVKI
1038
CDFGLARDIY
1048
KNPDYVRKTR
1060
LPLKWMAPES
1070

IFDKIYSTKS
1080
DVWSYGVLLW
1090
EIFSLGGSPY
1100
PGVQMDEDFC
1110
SRLREGMRMR
1120

APEYSTPEIY
1130
QIMLDCWHRD
1140
PKERPRFAEL
1150
VEKLGDLL
Residue
Distance (Å)
LEU833
3.963
VAL841
3.938
ALA859
3.884
VAL860
4.106
LYS861
3.309
GLU878
2.795
LEU882
3.856
ILE885
4.860
VAL891
4.136
VAL892
4.164
VAL907
3.623
VAL909
3.459
Residue
Distance (Å)
GLU910
2.925
TYR911
3.687
CYS912
2.932
LEU1013
3.526
CYS1018
4.738
HIS1020
3.930
LEU1029
3.484
ILE1038
3.657
CYS1039
3.177
ASP1040
2.844
PHE1041
3.769
References  Top
REF 1 Crystal structure of VEGFR1 in complex with N-(4-Chlorophenyl)-2-((pyridin-4-ylmethyl)amino)benzamide

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.