Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T64795 | Target Info | |||
| Target Name | Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) | ||||
| Synonyms | Voltage-gated calcium channel alpha subunit Cav3.1; Voltage-dependent T-type calcium channel; NBR13; Cav3.1c; CACNA1G | ||||
| Target Type | Successful Target | ||||
| Gene Name | CACNA1G | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Z 944 | Ligand Info | |||||
| Structure Description | calcium channel-ligand | PDB:6KZP | ||||
| Method | Electron microscopy | Resolution | 3.10 Å | Mutation | No | [1] |
| PDB Sequence |
NPWFERISML
89 VILLNCVTLG99 MFRPCEDIAC109 DSQRCRILQA119 FDDFIFAFFA129 VEMVVKMVAG 149 DTWNRLDFFI159 VIAGMLEYSL169 DLQNVSFSAV179 RTVRVLRPLR189 AINRVPSMRI 199 LVTLLLDTLP209 MLGNVLLLCF219 FVFFIFGIVG229 VQLWAGLLRN239 RCFLPENFSL 249 PLSVDLERYY259 QTENEDESPF269 ICSQPRENGM279 RSCRSVPTLR289 CVNWNQYYTN 322 CSAGEHNPFK332 GAINFDNIGY342 AWIAIFQVIT352 LEGWVDIMYF362 VMDAHSFYNF 372 IYFILLIIVG382 SFFMINLCLV392 VIATQFSETK402 QREIVDSKYF745 GRGIMIAILV 755 NTLSMGIEYH765 EQPEELTNAL775 EISNIVFTSL785 FALEMLLKLL795 VYGPFGYIKN 805 PYNIFDGVIV815 VISVWEIVSV832 LRTFRLMRVL842 KLVRFLPALQ852 RQLVVLMKTM 862 DNVATFCMLL872 MLFIFIFSIL882 GMHLFGCKFA892 SLPDRKNFDS908 LLWAIVTVFQ 918 ILTQEDWNKV928 LYNGMASTSS938 WAALYFIALM948 TFGNYVLFNL958 LVAILVEGFQ 968 FRLLCHRIIT1251 HKMFDHVVLV1261 IIFLNCITIA1271 MERPKIDPHS1281 AERIFLTLSN 1291 YIFTAVFLAE1301 MTVKVVALGS1321 SWNVLDGLLV1331 LISVIDILVS1341 MVSKILGMLR 1355 VLRLLRTLRP1365 LRVISRAQGL1375 KLVVETLMSS1385 LKPIGNIVVI1395 CCAFFIIFGI 1405 LGVQLFKGKF1415 FVCQGEDTRN1425 ITNKSDCAEA1435 SYRWVRHKYN1445 FDNLGQALMS 1455 LFVLASKDGW1465 VDIMYDGLDA1475 VGVDQQPIMN1485 HNPWMLLYFI1495 SFLLIVAFFV 1505 LNMFVGVVVE1515 NFHYLDLFIT1595 GVIGLNVVTM1605 AMEHYQQPQI1615 LDEALKICNY 1625 IFTVIFVLES1635 VFKLVAFGFR1645 RFFQDRWNQL1655 DLAIVLLSIM1665 GITLEEIEVN 1675 ASLPINPTII1685 RIMRVLRIAR1695 VLKLLKMAVG1705 MRALLDTVMQ1715 ALPQVGNLGL 1725 LFMLLFFIFA1735 ALGVELFGDL1745 ECDETHPCEG1755 LGRHATFRNF1765 GMAFLTLFRV 1775 STGDNWNGIM1785 KDTLRDYNTV1802 ISPIYFVSFV1812 LTAQFVLVNV1822 VIAVLMKHLE 1832 ESNK
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ASN388
4.666
LEU391
3.959
PHE868
4.912
LEU872
4.021
ILE876
4.412
PHE917
3.350
LEU920
3.356
THR921
3.443
GLN922
4.365
GLY951
3.117
|
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| Ligand Name: 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine | Ligand Info | |||||
| Structure Description | calcium channel-ligand | PDB:6KZP | ||||
| Method | Electron microscopy | Resolution | 3.10 Å | Mutation | No | [1] |
| PDB Sequence |
NPWFERISML
89 VILLNCVTLG99 MFRPCEDIAC109 DSQRCRILQA119 FDDFIFAFFA129 VEMVVKMVAG 149 DTWNRLDFFI159 VIAGMLEYSL169 DLQNVSFSAV179 RTVRVLRPLR189 AINRVPSMRI 199 LVTLLLDTLP209 MLGNVLLLCF219 FVFFIFGIVG229 VQLWAGLLRN239 RCFLPENFSL 249 PLSVDLERYY259 QTENEDESPF269 ICSQPRENGM279 RSCRSVPTLR289 CVNWNQYYTN 322 CSAGEHNPFK332 GAINFDNIGY342 AWIAIFQVIT352 LEGWVDIMYF362 VMDAHSFYNF 372 IYFILLIIVG382 SFFMINLCLV392 VIATQFSETK402 QREIVDSKYF745 GRGIMIAILV 755 NTLSMGIEYH765 EQPEELTNAL775 EISNIVFTSL785 FALEMLLKLL795 VYGPFGYIKN 805 PYNIFDGVIV815 VISVWEIVSV832 LRTFRLMRVL842 KLVRFLPALQ852 RQLVVLMKTM 862 DNVATFCMLL872 MLFIFIFSIL882 GMHLFGCKFA892 SLPDRKNFDS908 LLWAIVTVFQ 918 ILTQEDWNKV928 LYNGMASTSS938 WAALYFIALM948 TFGNYVLFNL958 LVAILVEGFQ 968 FRLLCHRIIT1251 HKMFDHVVLV1261 IIFLNCITIA1271 MERPKIDPHS1281 AERIFLTLSN 1291 YIFTAVFLAE1301 MTVKVVALGS1321 SWNVLDGLLV1331 LISVIDILVS1341 MVSKILGMLR 1355 VLRLLRTLRP1365 LRVISRAQGL1375 KLVVETLMSS1385 LKPIGNIVVI1395 CCAFFIIFGI 1405 LGVQLFKGKF1415 FVCQGEDTRN1425 ITNKSDCAEA1435 SYRWVRHKYN1445 FDNLGQALMS 1455 LFVLASKDGW1465 VDIMYDGLDA1475 VGVDQQPIMN1485 HNPWMLLYFI1495 SFLLIVAFFV 1505 LNMFVGVVVE1515 NFHYLDLFIT1595 GVIGLNVVTM1605 AMEHYQQPQI1615 LDEALKICNY 1625 IFTVIFVLES1635 VFKLVAFGFR1645 RFFQDRWNQL1655 DLAIVLLSIM1665 GITLEEIEVN 1675 ASLPINPTII1685 RIMRVLRIAR1695 VLKLLKMAVG1705 MRALLDTVMQ1715 ALPQVGNLGL 1725 LFMLLFFIFA1735 ALGVELFGDL1745 ECDETHPCEG1755 LGRHATFRNF1765 GMAFLTLFRV 1775 STGDNWNGIM1785 KDTLRDYNTV1802 ISPIYFVSFV1812 LTAQFVLVNV1822 VIAVLMKHLE 1832 ESNK
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VAL184
4.915
LEU185
4.132
PHE222
3.986
ASN339
2.980
ILE340
4.656
GLY341
3.722
TYR342
3.629
TRP344
3.747
ILE345
3.700
LEU353
4.071
PHE369
3.849
TYR370
3.946
PHE372
4.018
ILE373
4.113
SER831
4.202
VAL832
3.643
THR835
3.175
PHE836
3.774
LEU838
4.528
MET839
3.149
LEU842
4.974
LEU872
4.208
MET873
4.736
ILE876
3.758
ILE878
4.263
PHE879
4.391
LEU882
3.777
LEU886
3.942
LYS890
3.302
LEU910
3.685
ILE913
3.814
VAL914
3.927
PHE917
3.651
SER935
3.182
THR936
3.305
SER937
3.200
SER938
3.588
TRP939
3.822
ALA940
3.916
ALA941
4.790
LEU942
4.486
TYR943
4.170
ILE945
3.724
ALA946
3.815
LEU1386
4.659
VAL1393
4.151
CYS1396
4.300
CYS1397
3.569
PHE1400
4.193
ILE1402
4.609
PHE1403
3.142
LEU1406
3.938
LEU1410
4.234
LYS1414
4.768
PHE1457
4.496
ALA1460
4.073
SER1461
4.473
LYS1462
4.535
ASN1487
3.244
PRO1488
3.882
TRP1489
3.677
MET1490
3.659
LEU1491
3.904
LEU1492
3.679
TYR1493
4.709
ILE1495
3.692
SER1496
3.931
LEU1499
4.319
ILE1500
4.726
VAL1501
4.635
VAL1505
3.557
MET1508
4.242
VAL1603
4.907
ALA1606
3.906
MET1607
4.085
HIS1609
3.881
TYR1610
4.546
GLN1611
4.654
ARG1763
3.569
ASN1764
3.518
GLY1766
3.897
MET1767
3.689
PHE1769
4.221
LEU1770
3.943
THR1777
3.591
VAL1812
4.481
LEU1813
3.564
THR1814
4.030
GLN1816
3.672
PHE1817
3.415
VAL1820
3.835
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Cholesterol hemisuccinate | Ligand Info | |||||
| Structure Description | calcium channel-ligand | PDB:6KZP | ||||
| Method | Electron microscopy | Resolution | 3.10 Å | Mutation | No | [1] |
| PDB Sequence |
NPWFERISML
89 VILLNCVTLG99 MFRPCEDIAC109 DSQRCRILQA119 FDDFIFAFFA129 VEMVVKMVAG 149 DTWNRLDFFI159 VIAGMLEYSL169 DLQNVSFSAV179 RTVRVLRPLR189 AINRVPSMRI 199 LVTLLLDTLP209 MLGNVLLLCF219 FVFFIFGIVG229 VQLWAGLLRN239 RCFLPENFSL 249 PLSVDLERYY259 QTENEDESPF269 ICSQPRENGM279 RSCRSVPTLR289 CVNWNQYYTN 322 CSAGEHNPFK332 GAINFDNIGY342 AWIAIFQVIT352 LEGWVDIMYF362 VMDAHSFYNF 372 IYFILLIIVG382 SFFMINLCLV392 VIATQFSETK402 QREIVDSKYF745 GRGIMIAILV 755 NTLSMGIEYH765 EQPEELTNAL775 EISNIVFTSL785 FALEMLLKLL795 VYGPFGYIKN 805 PYNIFDGVIV815 VISVWEIVSV832 LRTFRLMRVL842 KLVRFLPALQ852 RQLVVLMKTM 862 DNVATFCMLL872 MLFIFIFSIL882 GMHLFGCKFA892 SLPDRKNFDS908 LLWAIVTVFQ 918 ILTQEDWNKV928 LYNGMASTSS938 WAALYFIALM948 TFGNYVLFNL958 LVAILVEGFQ 968 FRLLCHRIIT1251 HKMFDHVVLV1261 IIFLNCITIA1271 MERPKIDPHS1281 AERIFLTLSN 1291 YIFTAVFLAE1301 MTVKVVALGS1321 SWNVLDGLLV1331 LISVIDILVS1341 MVSKILGMLR 1355 VLRLLRTLRP1365 LRVISRAQGL1375 KLVVETLMSS1385 LKPIGNIVVI1395 CCAFFIIFGI 1405 LGVQLFKGKF1415 FVCQGEDTRN1425 ITNKSDCAEA1435 SYRWVRHKYN1445 FDNLGQALMS 1455 LFVLASKDGW1465 VDIMYDGLDA1475 VGVDQQPIMN1485 HNPWMLLYFI1495 SFLLIVAFFV 1505 LNMFVGVVVE1515 NFHYLDLFIT1595 GVIGLNVVTM1605 AMEHYQQPQI1615 LDEALKICNY 1625 IFTVIFVLES1635 VFKLVAFGFR1645 RFFQDRWNQL1655 DLAIVLLSIM1665 GITLEEIEVN 1675 ASLPINPTII1685 RIMRVLRIAR1695 VLKLLKMAVG1705 MRALLDTVMQ1715 ALPQVGNLGL 1725 LFMLLFFIFA1735 ALGVELFGDL1745 ECDETHPCEG1755 LGRHATFRNF1765 GMAFLTLFRV 1775 STGDNWNGIM1785 KDTLRDYNTV1802 ISPIYFVSFV1812 LTAQFVLVNV1822 VIAVLMKHLE 1832 ESNK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Y01 or .Y012 or .Y013 or :3Y01;style chemicals stick;color identity;select .A:224 or .A:225 or .A:228 or .A:232 or .A:275 or .A:276 or .A:277 or .A:367 or .A:368 or .A:370 or .A:371 or .A:373 or .A:374 or .A:377 or .A:381 or .A:758 or .A:762 or .A:764 or .A:765 or .A:766 or .A:1400 or .A:1401 or .A:1441 or .A:1447 or .A:1448 or .A:1449 or .A:1450 or .A:1451 or .A:1453 or .A:1454 or .A:1457 or .A:1801 or .A:1802 or .A:1805 or .A:1806 or .A:1809 or .A:1813; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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ILE224
3.760
PHE225
3.739
VAL228
3.743
LEU232
3.943
ARG275
4.876
GLU276
3.404
ASN277
3.681
HIS367
3.399
SER368
3.118
TYR370
3.116
ASN371
3.049
ILE373
3.978
TYR374
3.862
LEU377
4.025
VAL381
4.439
LEU758
4.176
ILE762
3.089
TYR764
3.384
HIS765
4.430
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cryo-EM structures of apo and antagonist-bound human Ca(v)3.1. Nature. 2019 Dec;576(7787):492-497. | ||||
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