Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T66011 | Target Info | |||
| Target Name | Complement factor B (CFB) | ||||
| Synonyms | Properdin factor B; PBF2; Glycinerich beta glycoprotein; Glycine-rich beta glycoprotein; GBG; Complement factor B Bb fragment; C3/C5 convertase; BFD; BF | ||||
| Target Type | Successful Target | ||||
| Gene Name | CFB | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Diisopropylphosphono Group | Ligand Info | |||||
| Structure Description | Crystal Structure Analysis of the Bb segment of Factor B complexed with Di-isopropyl-phosphate (DIP) | PDB:1RS0 | ||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | Yes | [1] |
| PDB Sequence |
SMNIYLVLDG
252 SDSIGASNFT262 GAKKVLVNLI272 EKVASYGVKP282 RYGLVTYATY292 PKIWVKVSEA 302 DSSNADWVTK312 QLNEINYEDH322 KLKSGTNTKK332 ALQAVYSMMS342 WPGWNRTRHV 358 IILMTDGLHN368 MGGDPITVID378 EIRDLLYIGK388 DRNPREDYLD399 VYVFGVGPLV 409 NQVNINALAS419 KKDNEQHVCK429 VKDMECLEDV439 FYQMIDESQS449 LSLCGMVWEH 459 RKGTDYHKQP469 WQAKISVIRK481 GHESCMGAVV491 SEYFVLTAAH501 CFTVDDKEHS 511 IKVSVGGEKR521 DLEIEVVLFH531 PNYNINGKKE541 AGIPEFYDYD551 VALIKLKNKL 561 KYGQTIRPIC571 LPCTEGTTRA581 LRLPPTTTCQ591 QQKEELLPAQ601 DIKALFVSEE 611 EKKLTRKEVY621 IKNGDKKGSC631 ERDAQYAPGY641 DKVKDISEVV651 TPRFLCTGGV 661 SPYADPNTCR671 GDSGGPLIVH681 KRSRFIQVGV691 ISWGVVDVCV709 PAHARDFHIN 719 LFQVLPWLKE729 KLQDEDLGFL739
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| Ligand Name: 4-Guanidinobenzoic acid | Ligand Info | |||||
| Structure Description | Crystal Structure Analysis of the Bb segment of Factor B complexed with 4-guanidinobenzoic acid | PDB:1RTK | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [1] |
| PDB Sequence |
SMNIYLVLDG
252 SDSIGASNFT262 GAKKVLVNLI272 EKVASYGVKP282 RYGLVTYATY292 PKIWVKVSEA 302 DSSNADWVTK312 QLNEINYEDH322 KLKSGTNTKK332 ALQAVYSMMS342 WPGWNRTRHV 358 IILMTDGLHN368 MGGDPITVID378 EIRDLLYIGK388 DRKNPREDYL398 DVYVFGVGPL 408 VNQVNINALA418 SKKDNEQHVC428 KVKDMECLED438 VFYQMIDESQ448 SLSLCGMVWE 458 HRKGTDYHKQ468 PWQAKISVIR478 KGHESCMGAV490 VSEYFVLTAA500 HCFTVDDKEH 510 SIKVSVGGEK520 RDLEIEVVLF530 HPNYNINGKK540 EAGIPEFYDY550 DVALIKLKNK 560 LKYGQTIRPI570 CLPCTEGTTR580 ALRLPPTTTC590 QQQKEELLPA600 QDIKALFVSE 610 EEKKLTRKEV620 YIKNGDKKGS630 CERDAQYAPG640 YDKVKDISEV650 VTPRFLCTGG 660 VSPYADPNTC670 RGDSGGPLIV680 HKRSRFIQVG690 VISWGVVDVC700 KRQKQVPAHA 713 RDFHINLFQV723 LPWLKEKLQD733 EDLGFL
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase. Mol Cell. 2004 Apr 9;14(1):17-28. | ||||
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