Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T66161 | Target Info | |||
| Target Name | Filamin A (FLNA) | ||||
| Synonyms | Nonmuscle filamin; Non-muscle filamin; Filamin-A; Filamin-1; Filamin 1; FLN1; FLN-A; FLN; Endothelial actin-binding protein; Endothelial actin cytoskeleton; Alpha-filamin; Actin-binding protein 280; ABP-280 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | FLNA | ||||
| Biochemical Class | Dystrophin protein | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Glutathione | Ligand Info | |||||
| Structure Description | Crystal structure of the filamin A repeat 21 complexed with the integrin beta7 cytoplasmic tail peptide | PDB:2BRQ | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [1] |
| PDB Sequence |
GGAHKVRAGG
2245 PGLERAEAGV2255 PAEFSIWTRE2265 AGAGGLAIAV2275 EGPSKAEISF2285 EDRKDGSCGV 2295 AYVVQEPGDY2305 EVSVKFNEEH2315 IPDSPFVVPV2325 ASPS
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The molecular basis of filamin binding to integrins and competition with talin. Mol Cell. 2006 Feb 3;21(3):337-47. | ||||
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