Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T68251 Target Info
Target Name Matrix metalloproteinase-2 (MMP-2)
Synonyms TBE-1; Matrix metalloproteinase 2; CLG4A; 72 kDa type IV collagenase; 72 kDa gelatinase
Target Type Successful Target
Gene Name MMP2
Biochemical Class Peptidase
UniProt ID
MMP2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: SC-74020 Ligand Info
Structure Description SOLUTION STRUCTURE OF A CATALYTIC DOMAIN OF MMP-2 COMPLEXED WITH SC-74020 PDB:1HOV
Method Solution NMR Resolution N.A. Mutation No [1]
PDB Sequence
MYNFFPRKPK
10
WDKNQITYRI
20
IGYTPDLDPE
30
TVDDAFARAF
40
QVWSDVTPLR
50

FSRIHDGEAD
60
IMINFGRWEH
70
GDGYPFDGKD
80
GLLAHAFAPG
90
TGVGGDSHFD
100

DDELWTNTSA
110
NYSLFLVAAH
120
EFGHAMGLEH
130
SQDPGALMAP
140
IYTYTKNFRL
150

SQDDIKGIQE
160
LYG
Residue
Distance (Å)
VAL42
3.261
GLY81
3.397
LEU82
2.566
LEU83
2.083
ALA84
2.131
HIS85
2.071
ALA86
3.635
PHE115
3.072
LEU116
2.596
VAL117
3.617
ALA119
3.606
HIS120
1.872
GLU121
1.987
HIS124
2.612
HIS130
2.784
PRO134
4.277
Residue
Distance (Å)
GLY135
4.854
ALA136
2.472
LEU137
2.058
MET138
4.724
ALA139
2.427
PRO140
2.726
ILE141
2.367
TYR142
2.377
THR143
2.746
TYR144
4.102
THR145
1.689
PHE148
2.039
ARG149
2.051
LEU150
2.845
SER151
4.279
References  Top
REF 1 Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor. Biochim Biophys Acta. 2002 Jul 29;1598(1-2):10-23.

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