Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T68383 | Target Info | |||
| Target Name | Bone morphogenetic protein 2 (BMP2) | ||||
| Synonyms | Bone morphogenetic protein 2A; BMP2A; BMP-2A; BMP-2 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | BMP2 | ||||
| Biochemical Class | Growth factor | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Mesotartaric acid | Ligand Info | |||||
| Structure Description | Crystal structure of the ternary RGMB-BMP2-NEO1 complex | PDB:4UI2 | ||||
| Method | X-ray diffraction | Resolution | 3.15 Å | Mutation | No | [1] |
| PDB Sequence |
KSSCKRHPLY
302 VDFSDVGWND312 WIVAPPGYHA322 FYCHGECPFP332 LADHLNSTNH342 AIVQTLVNSV 352 NSKIPKACCV362 PTELSAISML372 YLDENEKVVL382 KNYQDMVVEG392 CGCR |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein. Nat Struct Mol Biol. 2015 Jun;22(6):458-65. | ||||
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