Binding Site Information of Target

Content Navigation (  All   None )                                      
Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T69685 Target Info
Target Name Glycine transporter GlyT-1 (SLC6A9)
Synonyms Solute carrier family 6 member 9; Sodium- and chloride-dependent glycine transporter 1; Glycine type-1 transporter; Glycine transporter type 1; GlyT1; GlyT-1
Target Type Clinical trial Target
Gene Name SLC6A9
Biochemical Class Neurotransmitter:sodium symporter
UniProt ID
SC6A9_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: [5-Fluoranyl-6-(oxan-4-yloxy)-1,3-dihydroisoindol-2-yl]-[5-methylsulfonyl-2-[2,2,3,3,3-pentakis(fluoranyl)propoxy]phenyl]methanone Ligand Info
Structure Description Inward-open structure of human glycine transporter 1 in complex with a benzoylisoindoline inhibitor and sybody Sb_GlyT1#7 PDB:6ZBV
Method X-ray diffraction Resolution 3.40 Å Mutation Yes [1]
PDB Sequence
RGNWGNQIEF
109
VLTSVGYAVG
119
LGNVWRFPYL
129
CYRNGGGAFM
139
FPYFIMLIFC
149

GIPAFFMELS
159
FGQFASQGCL
169
GVWRISPMFK
179
GVGYGMMVVS
189
TYIGIYYNVV
199

ICIAFYYFFS
209
SMTHVLPWAY
219
CNNPWNTHDC
229
AGVLDLTHSL
259
QRTSPSEEYW
269

RLYVLKLSDD
279
IGNFGEVRLP
289
LLGCLGVAWL
299
VVFLCLIRGV
315
VYFTATFPYV
325

VLTILFVRGV
335
TLEGAFDGIM
345
YYLTPQWDKI
355
LEAKVWGDAA
365
SQAFYSLGCA
375

WGGLITMASY
385
NKFHNNCYRD
395
SVIISITNCA
405
TSVYAGFVIF
415
SILGFMANHL
425

GVDVSRVADH
435
GPGLAFVAYP
445
EALTLLPISP
455
LWSLLFFFML
465
ILLGLGTQFC
475

LLETLVTAIV
485
DEVGNEWILQ
495
KKTYVTLGVA
505
VAGFLLGIPL
515
TSQAGIYWLL
525

LMDNYAASFS
535
LVVISCIMCV
545
AIMYIYGHRN
555
YFQDIQMMLG
565
FPPPLFFQIC
575

WRFVSPAIIF
585
FILVFTVIQY
595
QPITYNHYQY
605
PGWAVAIGFL
615
MALSSVLCIP
625

LYAMFRLART
635
DGDTLLQRLK
645
NATKPSRDWG
655
PALLEHRTG
Residue
Distance (Å)
TYR116
2.594
ALA117
2.564
VAL118
3.355
GLY119
2.027
LEU120
3.231
GLY121
1.840
ASN122
2.615
PHE154
2.908
LEU158
2.597
TYR196
3.337
GLN367
4.744
TYR370
2.663
SER371
2.218
LEU372
3.944
GLY373
2.174
Residue
Distance (Å)
TRP376
2.357
GLY378
2.524
LEU379
2.964
MET382
2.525
ALA383
2.422
ASN386
3.025
ASN390
4.144
ASP395
3.773
ILE399
2.736
ASN403
2.457
GLY471
4.435
THR472
1.724
CYS475
2.917
LEU476
2.968
THR479
3.063
Click to View More Binding Site Information of This Target and Ligand Pair
References  Top
REF 1 Structural insights into the inhibition of glycine reuptake. Nature. 2021 Mar;591(7851):677-681.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.