Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T70234 | Target Info | |||
| Target Name | Ephrin type-A receptor 4 (EPHA4) | ||||
| Synonyms | hEK8; Tyrosineprotein kinase receptor SEK; Tyrosineprotein kinase TYRO1; Tyrosine-protein kinase receptor SEK; Tyrosine-protein kinase TYRO1; TYRO1; SEK; Ephrin typeA receptor 4; EPHlike kinase 8; EPH-like kinase 8; EK8 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | EPHA4 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 1-Propanol | Ligand Info | |||||
| Structure Description | Crystal Structure of the EphA4 Ligand Binding Domain | PDB:2WO1 | ||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | No | [1] |
| PDB Sequence |
ETGEVTLLDS
36 RSVQGELGWI46 ASPLEGGWEE56 VSIMDKNTPI67 RTYQVCNVME77 PSQNNWLRTD 87 WITREGAQRV97 YIEIKFTLRD107 CNSLPGVMGT117 CKETFNLYYY127 ESDNDKERFI 137 RENQFVKIDT147 IAADESFTQV157 DDRIMKLNTE169 IRDVGPLSKK179 GFYLAFQDVG 189 ACIALVSVRV199 FYKRTKHHHH209
|
|||||
|
|
||||||
| Ligand Name: 1,3-Butanediol | Ligand Info | |||||
| Structure Description | Structure of the EphA4 LBD in complex with peptide | PDB:4W50 | ||||
| Method | X-ray diffraction | Resolution | 2.42 Å | Mutation | Yes | [2] |
| PDB Sequence |
GNEVTLLDSR
37 SVQGELGWIA47 SPLEGGWEEV57 SIMDEKNTPI67 RTYQVCNVME77 PSQNNWLRTD 87 WITREGAQRV97 YIEIKFTLRD107 CNSLPGVMGT117 CKETFNLYYY127 ESDNDKERFI 137 RENQFVKIDT147 IAADESFTQV157 DIGDRIMKLN167 TEIRDVGPLS177 KKGFYLAFQD 187 VGACIALVSV197 RVFYKKA
|
|||||
|
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling. Structure. 2009 Oct 14;17(10):1386-97. | ||||
| REF 2 | Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor. ACS Chem Biol. 2014 Dec 19;9(12):2787-95. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.